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Identifier	000388637
Title	Συνθετικές προσεγγίσεις σε δομές παραγώγων του κοστικού οξέος
Alternative Title	Synthetic approaches to costic acid analogs
Author	Μενούνου, Γεωργία Μ
Thesis advisor	Κατερινόπουλος, Χαράλαμπος Ε
Reviewer	Ορφανόπουλος, Μιχαήλ Βασιλικογιαννάκης, Γεώργιος
Abstract	This research project includes a number of synthetic approaches and the development of relevant synthetic methodology for the preparation of a series of synthetic analogs of Costic Acid, a compound isolated from the plant Dittrichia viscosa (Greek: Aconiza), which kills the parasitic mite of honey bee Varroa destructor without damaging the insect . The synthetic approaches followed, include the introduction of additional carboxylic moieties on the carbon backbone of Costic Acid as well as “structural simplifications” on the bicyclic carbon framework. Specifically, one of the synthetic approaches used as starting reactant, the commercially available compound of 1,7-dihydroxynaphthalene and through a series of reactions the synthesis of the target compound dimethyl-2-(8-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl) malonate was achieved. Then, an attempt was made to modify the carbon framework of Costic Acid regarding the presence of the methyl group located at the fusion point of the bicyclic system. To this purpose, commercially available compound cyclohexanone (60a) was used, but, even in the early stages of the synthesis this approach was found to be problematic and the desired products were not formed. The last synthetic approach involved the use of methylcyclohexanone (60b) as a starting material in a series of approaches to the target compound, namely, dimethyl 2- (4a-methyl-8-methylene-2,3,4,4a, 5,6,7,8-octahydro-2-napthalenyl) malonate.
Language	Greek
Subject	Costic acid
	Κοστικό οξύ
Issue date	2014-11-21
Collection	School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/0/c/c/metadata-dlib-1416470101-516023-24977.tkl
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