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Identifier	000401228
Title	Ανίχνευση των χημειοκίνων στο περιτοναϊκό υγρό γυναικών με ενδομητρίωση και ο πιθανός ρόλος τους στις τοπικές φλεγμονώδεις αντιδράσεις
Alternative Title	Peritoneal fluid concentrations of B-chemokines in endometriosis and their role in local inflammatory reactions
Author	Μάργαρη, Καλλιόπη-Μαρία
Thesis advisor	Ματαλλιωτάκης, Ιωάννης
Reviewer	Κουμαντάκη, Ευγένιο Αθανασάκη, Ειρήνη Γκίκας, Αχιλλέας Γανωτάκης, Εμμανουήλ Τσατσάνης, Χρήστος Γιαννακοπούλου, Χριστίνα
Abstract	Objective: To examine whether the levels of MCP-1, RANTES and MCP-3 in the peritoneal fluid correlate with endometriosis. Study design: Patients with endometriosis were compared with controls. Setting: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. Subjects: This study involved 95 women of reproductive age who were undergoing laparoscopy for evaluation of infertility or for pelvic pain. They were divided into an endometriosis group (n=54) and a contril group (n=41). Interventions: peritoneal fluid samples were obtained and β- chemokines (MCP-1, RANTES and MCP-3) were measured using ELISA. Statistical analysis: Mean and median values were used to present values. Due to the non- normality of chemokines, a log transformation was applied. Differences were examined using independent samples t-test. One way ANOVA and Turkey HSD multiple comparison post hoc tests were applied. A significance level at 0,05 was set. Results: The levels of MCP-1 are higher (p for log values=0,024) in the control group (mean=687,6, SD=467,7 pg/ml) than those of the endometriosis group (mean=570,4, SD=633,1 pg/ml). The same is true for the median values of MCP-1 (control median= 568,5, endometriosis median=384,7 pg/ml). MCP-3 and RANTES do not differ significantly ( MCP-3 p=0,787, RANTES p=0,153). The levels of MCP-1 in patients with stage II endometriosis are significantly lower in comparison with stage III (p=0,0048) and stage IV (p-0,033) endometriosis. Conclusions: A decrease in the concentrations in MCP-1 in stage I endometriosis has been observed, which is even larger in stage II, in contrast to stage III and stage IV endometriosis, which exhibit concentrations similar to controls.
Language	Greek
Issue date	2016-07-19
Collection	School/Department--School of Medicine--Department of Medicine--Doctoral theses
	Type of Work--Doctoral theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/e/9/3/metadata-dlib-1464778100-404565-30931.tkl
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