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Identifier |
000381327 |
Title |
Επίδραση αντιρθομβωτικών φαρμάκων στον κυτταρικό πολλαπλασιασμό και την οστεογενή διαφοροποίηση προ-οστεοβλαστών |
Alternative Title |
Effects of antithrombotic drugs on in vitro cell proliferation and osteogenic differentiation in pre-osteoblasts |
Author
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Μάλλη, Αικατερίνη
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Thesis advisor
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Χατζηνικολαϊδου, Μαρία
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Reviewer
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Βαμβακάκη, Μαρία
Γανωτάκης, Δημήτριος
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Abstract |
The bone is a vital and dynamic tissue, perfectly designed to perform basic functions. After a bone damaging, starts bone wounding , one of the most complex procedures to restore bone without scar formation through the coordinated action of osteoclasts and osteoblasts. In clinical practice , administration of antithrombotic drugs in postoperative orthopedic surgery patients effective for the prevention of venous thromboembolism . Besides antithrombotic nature, these medicines may affect
the healing of bone defects .The present study focuses on effect of different concentrations of antithrombotic drugs in proliferation and differentiation of pre-osteoblastic cells MC3T3-E1. The induction drugs caused a positive impact on viability and multiplication. The differentiation markers exhibit variable
results in the range of concentrations studied. Furthermore, my work studies the interaction of pre-osteoblastic cells with alumina ( Al2O3 ), a bioinert ceramic material with excellent mechanical properties. Because of the high hardness and strength
corrosion of the alumina may be used in orthopedic and dentistry. I present a viability study and growth of pre-osteoblastic cells in the ceramic material as this criterion biocompatibility. The results show an increase in cell proliferation in both pore sizes (320 and 560 μm ) used with 75% porosity, with the largest increase occurring in material with larger pore size.
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Language |
Greek |
Subject |
MC3T3-E1 |
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Αντιθρομβωτικά φάρμακα |
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Οsteogenesis |
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Οστεογένεση |
Issue date |
2013-11-15 |
Collection
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School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/b/0/e/metadata-dlib-1386588426-901738-28885.tkl
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Views |
233 |