Results - Details
Search command : Author="Μπούμπας"
And Author="Δημήτριος"
Current Record: 9 of 56
|
Identifier |
000390076 |
Title |
Investigate the role of autophagy in the Myeloid Derived Suppressor Cells -mediated tolerance of anti-tumor responses |
Alternative Title |
Μελέτη του ρόλου της αυτοφαγίας στην ανοσολογική ανοχή που επάγεται απο τα κατασταλτικά κύτταρα της μυελικής σειράς στις αντικαρκινικές αποκρίσεις |
Author
|
Μίντζας, Κωνσταντίνος
|
Thesis advisor
|
Βεργίνης, Παναγιώτης
|
Reviewer
|
Μπούμπας, Δημήτριος
Χαμηλός, Γεώργιος
|
Abstract |
Recruitment of suppressive immune cell types in tumor sites is a major manifestation
of tumor tolerance. Myeloid-derived suppressor cells (MDSCs) play a very important
role in the suppression of anti-tumor immunity by expressing several suppressive
molecules and by expanding regulatory T cells. However, the exact molecular
mechanism of MDSCs-Treg interaction is not yet fully understood. Autophagy, apart
from its homeostatic role, has been implicated in antigen presentation through MHC
class II molecules in antigen-presenting cells, but its implication in regulatory T cell
expansion by MDSCs has not been studied. In this study, we observed an expansion
of MDSCs in tumor-bearing mice that is accompanied by an increase in the expression
of the autophagy-related genes Atg5 and Bcl1. Mice with a conditional knock-out of
Atg5 gene in myeloid cells (LysMcreAtg5fl/fl) showed decreased tumor growth compared
to control tumor-bearing mice. Furthermore, LysMcreAtg5fl/fl mice showed a markedly
expansion of MDSCs in spleen compared to control mice and a differential expression
of several effector molecules (TGFβ, arginase-1 and CEBP/β) in these cells.
Collectively, these results support an important role for autophagy in the function of
myeloid cells and additional experiments will elucidate the molecular mechanism
underlying tumor tolerance by MDSCs.
|
Language |
English |
Subject |
Autophagy |
|
Cancer |
|
Suppressor cells |
|
Tolerance |
|
Ανοσολογική ανοχή |
|
Αυτοφαγία |
|
Καρκίνος |
|
Κατασταλτικά κύτταρα |
Issue date |
2014-12-04 |
Collection
|
School/Department--School of Medicine--Department of Medicine--Post-graduate theses
|
|
Type of Work--Post-graduate theses
|
Permanent Link |
https://elocus.lib.uoc.gr//dlib/1/5/2/metadata-dlib-1423757957-131318-32363.tkl
|
Views |
264 |