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Identifier |
000443462 |
Title |
The role of macrophages bearing DNA damage in CD4+ T-cell function |
Alternative Title |
Ο ρόλος μακροφάγων με γενετικές βλάβες στη λειτουργία των CD4 T λεμφοκυττάρων |
Author
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Αρβανιτάκη, Ερμιόνη Σ.
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Thesis advisor
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Γαρίνης, Γεώργιος
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Reviewer
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Βεργίνης, Παναγιώτης
Μπέρτσιας, Γεώργιος
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Abstract |
During aging, a multitude of changes occurs, directly affecting immune system
integrity and creating an environment of low-grade, chronic inflammation irrespective
of pathogen encounter. DNA damage plays a pivotal role in the process of cellular
aging, triggering a cascade of stress responses that are sensed within the cell.
Through intercellular communication, a series of phenotypic changes then emerge at
a systemic level. Previous work in our lab by Goulielmaki et al. (2020) showed that
DNA-repair deficient macrophages (in the Ercc1F/-; Lys-Cre+ mouse model) initiate a
systemic pro-inflammatory response and metabolic reprogramming, which is
accompanied by the secretion of extracellular vesicles (EVs). In this study, we focus
on the communication of macrophages and CD4+ T cells, which together coordinate
a productive immune response that aged individuals lack. First, we characterize the
functionality of DNA-repair proficient CD4+ T cells in an altered inflammation
environment. We find that T cells become hypo-functional in response to the
accumulation of DNA damage in macrophages. Next, we suggest macrophages in
this setting are both potential activators and, later, suppressors of CD4+ T cells, and
we propose mechanisms by which this communication might be achieved.
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Language |
English |
Issue date |
2021-11-26 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/d/6/1/metadata-dlib-1636529731-206740-10710.tkl
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Views |
318 |
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