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Identifier 000423514
Title Electrophysiological and morphological identification of neurons of the inferior colliculus
Alternative Title Ηλεκτροφυσιολογική και μορφολογική ταυτοποίηση νευρώνων του κάτω διδυμίου
Author Κολαξή, Αγγελική
Thesis advisor Δαλέζιος, Ιωάννης
Reviewer Μοσχοβάκης, Αντώνης
Σίμος, Παναγιώτης
Abstract The Inferior Colliculus (IC) is a midbrain structure playing a critical role in the central auditory system. It is divided into three main subdivisions: The Central Nucleus (CIC), the External Cortex (ECIC), and the Dorsal Cortex (DCIC). It is also involved in the oculomotor pathway, sending projections to the superior colliculus, providing auditory information to a structure contributing to the generation of saccades. In this study, we identified inferior collicular neurons of the rat using an array of methods, i.e. in vivo extracellular recordings followed by juxtacellular labeling of single ECIC neurons and reconstruction of them, combined with immunocytochemistry and electron microscopical observation, in order to characterize as completely as possible the IC neurons. We present data from two ECIC neurons (PS35 and PS41). Neuron PS35 increases its firing rate during auditory stimulation, is giant and multipolar, projects to the contralateral IC and medial geniculate body, expresses parvalbumin and is, most likely, GABAergic. Neuron PS41, decreases its firing rate during auditory stimuli, has a small ovoid bipolar soma and its dendritic tree extends ventrally to it. The axon projects to the contralateral IC and enters the ipsilateral superior colliculus forming type I (most likely excitatory) synapses with dendritic spines. This was a first attempt to identify inferior collicular neurons, using this array of methods. Our results match to the existing literature and enrich it, providing deeper knowledge of how neuronal circuits process sensory information and control our behavior.
Language English, Greek
Issue date 2019-07-17
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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