Results - Details
Search command : Author="Βελώνια"
And Author="Καλλιόπη"
Current Record: 6 of 23
|
Identifier |
000453109 |
Title |
Synthesis of functional protein-polymer conjugates and biodegradable polymers |
Alternative Title |
Σύνθεση λειτουργικών υβριδίων πρωτεϊνης πολυμερούς και βιοδιασπώμενων πολυμερών |
Author
|
Μπαλτζάκη, Μαρία Χρυσή Ιζαμπέλλα
|
Thesis advisor
|
Βελώνια, Καλλιόπη
|
Reviewer
|
Αρματάς, Γεράσιμος
Ρανέλλα, Ανθή
|
Abstract |
Protein-polymer conjugates are biohybrid macromolecules designed to combine the functionality, activity and selectivity of biomolecules with the stability and vast chemical diversity of synthetic polymers. Such protein-polymer chimeras can either retain their original features or display new physical and/or chemical properties not seen in the individual moieties -such as phase separation or self-assembling behaviour- while, at the same time the stability, biocompatibility and solubility of the parent protein can be potentially improved. In the past few years, protein-polymer conjugates have gained interest due to their potential for applications in many fields ranging from nanotechnology to biomedicine.
Recently, oxygen-tolerant, copper-mediated (photo)polymerization approaches were developed for the grafting of a variety of monomers from different proteins without the need for deoxygenation or other tedious reaction conditions. This Thesis contributed to the evaluation of the optimal conditions of an oxygen-tolerant, aqueous copper-mediated polymerization approach, and its scaling up. Aiming to expand the scope, the grafting from different proteins was explored. More importantly, based on this synthetic method, an alternative, ligand-free synthetic procedure was developed to readily afford protein-polymer bioconjugates. A plethora of monomers including styrene, acrylates, methacrylates, acrylamides and renewable monomers were grafted from protein macroinitiators to yield a wide variety of biohybrids with amphiphilic or hydrophilic character as well as triblock bioconjugates exhibiting interesting self-assembling patterns.
In parallel, in the context of the “Biowaste to Bioplastic” program B2B, PLLA was synthesised via azeotropic dehydration followed by polycondensation polymerization and characterized.
|
Language |
English |
Subject |
Βιοδιασπώμενα πολυμερή |
Issue date |
2022-11-23 |
Collection
|
School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Post-graduate theses
|
|
Type of Work--Post-graduate theses
|
Permanent Link |
https://elocus.lib.uoc.gr//dlib/6/0/3/metadata-dlib-1672823864-492664-13875.tkl
|
Views |
415 |
Digital Documents
|
|
No permission to view document.
It won't be available until: 2025-11-23
|