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Identifier |
000444106 |
Title |
Investigation of the role of microglial autophagy in the mouse model of multiple sclerosis. |
Alternative Title |
Μελέτη του ρόλου της μικρογλοιακής αυτοφαγίας στο ζωικό μοντέλο της σκλήρυνσης κατά πλάκας. |
Author
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Ορφανάκης, Μιχαήλ
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Thesis advisor
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Βεργίνης Παναγιώτης
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Abstract |
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of central
nervous system (CNS). Microglia are tissue – resident macrophages implicated in
central nervous system development, homeostasis and response to injury. In the case
of MS microglia are the first cells to arrive to the MS lesions to clear tissue debris in
order to restore CNS homeostasis. However, microglia cells are proposed to also
contribute to MS development. This hypothesis suggests that impaired microglial
autophagy manage to affect MS development. Here, we demonstrate that microglial
autophagy is induced upon experimental autoimmune encephalomyelitis (EAE) in
mice, a well established mouse model to study MS. Primary neo – natal microglia
treated for 18h with LPS, IFNγ or IFNα failed to recapitulate the induced autophagy
upon EAE development. Surprisingly, LPS treatment manage to induce the p62
expression and decrease autophagy in primary microglia even though LPS treatment
is well established to induce autophagy in macrophages through TLR4 signaling.
Further research need to be done in vivo in order to unravel how and if microglia
contribute to EAE/MS development.
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Language |
English |
Subject |
Αυτοφαγία |
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Μικρόγλοια |
Issue date |
2021-12-01 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/7/c/0/metadata-dlib-1639225330-865260-15038.tkl
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Views |
263 |
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