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Identifier

000440910

Title

Ο ρόλος του ιού Parvovirus B19 στον καρκίνο του θυρεοειδούς αδένα

Alternative Title

The role of parvovirus B19 in thyroid cancer

Author

Νaσίκας, Δημήτριος Κ.

Thesis advisor

Σουρβίνος, Γεώργιος

Reviewer

Χαλκιαδάκης, Γεώργιος
Τζαρδή, Μαρία
Ζώρας, Οδυσσέας Ιωάννης
Συμβουλάκης, Εμμανουήλ
Ζαφειρόπουλος, Αλέξανδρος
Λασιθιωτάκης, Κωνσταντίνος

Abstract

During the last decade, an emerging number of studies have investigated the role of Parvovirus B19 (B19V) presence in thyroid disease. However, no clear evidence considering the presence of Parvovirus B19 in thyroid cancer cells and normal thyroid epithelial cells has been established to date and thus sufficient supporting data associating Parvovirus B19 to thyroid pathology are missing. In the present study, we sought to investigate the presence of Parvovirus B19 in both abnormal and normal adjacent thyroid tissue specimens after total thyroidectomy as well as the extent that this phenomenon occurs in a population group referred to a tertiary surgical oncology department. We examined both abnormal and normal adjacent thyroid tissue specimens from forty-one patients who underwent total thyroidectomy for thyroid disease (cancerous or benign) within a 3-year period in a tertiary surgical oncology department. Parvovirus B19 viral gene sequence was amplified by Real-Time PCR. Hashimoto’s thyroiditis, thyroid gland weight, maximum size of the predominant thyroid nodule as well as sex and age of the patients were also evaluated in respect to the Parvovirus B19 presence. Parvovirus B19 virus genome was detected in 21/41 (51.2%) patients thyroid tissue samples. No statistically significant difference was noted regarding the sex, age, postoperative diagnosis, thyroid weight and maximum nodule diameter and presence of multifocal disease. The correlation between the incidence of Hashimoto Thyroiditis and absence of Parvovirus B19 genome was statistically significant. Our findings showed high prevalence of Parvovirus B19 DNA in thyroid tissue disease in the population examined. Its actual role of the virus and its potential implication in the development or progression of thyroid diseases remain to be elucidated. Larger cohort studies are needed in order to validate a quasi-mutually exclusive role of Hashimoto’s thyroiditis and Parvovirus B19 presence in thyroid disease in terms of geographical distribution.

Language

Greek

Subject

Real -time PCR

Θυρεοειδίτιδα Hashimoto

Καρκίνος θυροειδούς

Issue date

2021-07-30

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

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