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| Identifier |
000438216 |
| Title |
Κυκλίνες και αναστολείς των κυκλινο-εξαρτώμενων κινασών ως βιοδείκτες πρόγνωσης στο μελάνωμα |
| Alternative Title |
Cyclins and cyclin dependent kinase inhibitors as biomarkers of prognosis in melanoma |
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Author
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Ιωάννου, Μαρίνα
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Thesis advisor
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De Bree, Eelco
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Reviewer
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Τζαρδή, Μαρία
Ζώρας, Οδυσσέας
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| Abstract |
Melanoma of the skin is a malignant tumor and is the most aggressive and lethal form of
malignant skin tumor. The epidemiological features of melanoma vary depending on the race,
geographical area, age, histological type and location of the disease. The survival of patients
with melanoma varies greatly within the same category of the TNM staging system. Even
after appropriate surgical resection of the primary melanoma, metastatic disease is observed
in a significant percentage. Therefore, there is a great need to identify patients at increased
risk of recurrence at initial diagnosis, in order to provide adjuvant treatment to those patients.
Of particular interest are prognostic biomarkers, which can provide an assessment of
aggression, the likelihood of metastasis, and the overall outcome of the disease. To date, very
important clinical and pathological prognostic factors have been found, such as presence of
nodal metastases, Breslow infiltration depth and the presence of ulceration. Nevertheless,
melanoma exhibits unpredictable biological behavior and established prognostic factors do
not fully reflect the observed differences in disease-related survival. Therefore, it is important
to constantly identify new prognostic biomarkers that will more accurately assess the overall
outcome of the disease.
We know that cyclins and cyclin-dependent kinase inhibitors play an important role in
regulating the cell cycle of melanocytes. In the present study, in the context of my master's
thesis, we aim to study the prognostic value of the expression relationship between cyclin and
cyclin-dependent inhibition of kinases and to investigate whether these proteins can be
predictive biomarkers in skin melanoma. For this purpose, an extensive review of the
literature in the PubMed database was performed.
According to the results, cyclin D3 and cyclin A could be prognostic markers for overall
survival and disease-free survival in superficial growth melanoma. The p16 inhibitor plays an
important role as a prognostic marker in melanoma. It is associated with overall survival and
disease-free survival regardless of the known prognostic indicators of Breslow infiltration
depth and ulceration. Equally important is the association of the p16 inhibitor with lymph
node metastases and can be a useful prognostic factor in assessing the condition of lymph
nodes in melanoma. The p27 inhibitor also appears to be associated with survival in
metastatic melanoma and could be a potentially prognostic factor with a poor prognosis in
stage III and IV patients. Finally, the expression of the p14 inhibitor appears in the literature
to play an important role in melanoma because although it is not associated with survival and
recurrence, it is associated with lymph node metastases and Breslow infiltration depth.
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| Language |
Greek, English |
| Subject |
Μελάνωμα |
| Issue date |
2021-03-29 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/1/a/4/metadata-dlib-1616589348-270405-19009.tkl
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| Views |
335 |
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