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Title |
Μελέτη της αυτοφαγίας σε ολιγοδενδροκύτταρα γηραιών μυών |
Alternative Title |
Study of autophagy in oligodendrocytes of aged mice |
Author
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Θώμογλου, Ευσταθία
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Thesis advisor
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Καραγωγέως, Δόμνα
Σιδηροπούλου, Κυριακή
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Abstract |
(Macro)autophagy constitutes an essential, evolutionary conserved degradation pathway, that leads cytoplasmic material such as proteins, organelles, even pathogens to lysosomes for degradation. Genetic inhibition of autophagy, through the ablation of core autophagic genes, in oligodendrocytes in mice, causes significant myelin disruption, axon degeneration and accumulation of myelin proteins in oligodendrocytes. However, the role of autophagy in oligodendrocytes in ageing is not extensively studied. In this study, genetic inhibition of autophagy was achieved through the ablation of atg5, a core autophagic gene, in mouse oligodendrocytes. Central nervous system (CNS) tissues from 22 month old transgenic mice were histologically examined, in order to observe myelin and axon phenotypes, as well as microglial and astrocytes populations. Mice deficient in autophagy in oligodendrocytes, exhibit significant myelin membrane decompaction, axon degeneration and higher microglia density, indicating that autophagy in oligodendrocytes is an essential mechanism for the maintenance of CNS myelin homeostasis in ageing.
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Language |
Greek |
Subject |
Ageing |
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CNS |
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Microglial cells |
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Myelin |
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Γήρανση |
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ΚΝΣ |
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Μικρογλοιακά κύτταρα |
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Μυελίνη |
Issue date |
2023-11-24 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Graduate theses
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Type of Work--Graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/f/c/e/metadata-dlib-user1701362885-20995.tkl
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Views |
228 |