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| Identifier |
000457041 |
| Title |
Development and integration of wavefront shaping techniques in a multiparametric microscope |
| Alternative Title |
Ανάπτυξη και ενσωμάτωση τεχνικών ελέγχου μετώπου κύματος σε πολυπαραμετρικό μικροσκόπιο |
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Author
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Διβάρης, Γεράσιμος Γ.
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Thesis advisor
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Μακρής, Κωνσταντίνος
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Reviewer
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Ζαχαράκης, Ιωάννης
Κομίνης, Ιωάννης
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| Abstract |
Developing already existing microscopy systems by introducing new techniques and means
or creating new microscopes is a vital part to better studying biological samples or systems
and making advances in medical-related fields. By combining many different methods in a
multiparametric microscope, such as two-photon microscopy, Raman spectroscopy, and
photoacoustic imaging and further enhancing the stand-alone techniques can result in the
imaging of different types of biological molecules at the same time. In addition to the
reduction in imaging time achieved through the concurrent utilization of multiple techniques,
the complementary nature of these methods allows for the acquisition of supplementary
information, resulting in more comprehensive and detailed final images and in better
understanding of the sample itself. Therefore, this represents a leap forward towards more
accurate surgical procedures and more targeted medical treatments. In this Master thesis, the
main goal was to improve photoacoustic imaging by introducing a Bessel Beam in the place of
the Gaussian one and manipulating the Bessel beam with wavefront shaping techniques in
order to suppress its side lobes and retain mainly the central lobe with the maximum intensity
(Droplet Beam). By achieving this, due to the non-diffracting properties of the Bessel beam,
we would attain a much larger imaging depth than with its Gaussian counterpart because of
the greater Depth Of Field of this beam and therefore be able to get photoacoustic images in
much greater depths in biological tissue than ever before along with higher resolution. The
use of this greater imaging depth is dictated by the nature of the biological samples that have
curvature and consist of many layers. With the use of a Gaussian beam, we can image a single
layer in high resolution while with the utilization of this so-called Droplet beam, we would be
able to image multiple layers at high resolution simultaneously.
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| Language |
English |
| Subject |
Bessel beams |
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Photoacoustic imaging |
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Δέσμες Bessel |
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Τεχνικές ελέγχου μετώπου κύματος |
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Φωτοακουστική απεικόνιση |
| Issue date |
2023-07-28 |
| Collection
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School/Department--School of Sciences and Engineering--Department of Physics--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/8/7/e/metadata-dlib-1688975070-446975-14308.tkl
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| Views |
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