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Identifier	000416942
Title	Μελέτη των μεταβολών της ελαστικότητας του οφθαλμού σε ασθενείς με μη παραγωγική διαβητική αμφιβληστροειδοπάθεια
Alternative Title	Ocular rigidity measurement in patients with non proliferative diabetic retinopathy
Author	Παναγιώτογλου, Θεονίτσα Δ.
Thesis advisor	Τσιλιμπάρης, Μιλτιάδης
Reviewer	Παλλήκαρης, Ιωάννης Σιγανός, Χαράλαμπος Κυμιωνής, Γεώργιος Μαρής, Θωμάς Ζώρας, Οδυσσέας Δαφνής, Ευγένιος
Abstract	PURPOSE: To compare ocular rigidity (OR) and outflow facility (C) in patients with non-proliferative diabetic retinopathy (NPDR) and control subjects. METHODS: Twenty-four patients with NPDR (NPDR-group) and 24 controls (control group) undergoing cataract surgery were enrolled. NPDR-group was further divided in patients with mild NPDR (NPDR1-group) and patients with moderate and/or severe NPDR (NPDR2-group). After cannulation of the anterior chamber, a computer-controlled device, featuring a motor-driven syringe and a pressure sensor, was used to infuse saline and increase the intraocular pressure (IOP) in a stepping procedure from 15 to 40 mm Hg. The intraocular pressure was continuously recorded for 2 seconds after each infusion step. Ocular rigidity and outflow facility coefficients were estimated from intraocular pressure and volume recordings. RESULTS: Ocular rigidity was 0.0205 ± 0.125μl-1 in NPDR group and 0.0202 ± 0.0118μl-1 in control group (p = 0.942). In NPDR1-group, ocular rigidity was 0.017 ± 0.009 and in NPDR2-group it was 0.025 ± 0.015μl-1 (p = 0.192). Outflow facility was 0.120 ± 0.048 μl/min/mmHg in NPDR-group compared to 0.153 ± 0.078μl/min/mmHg in the control-group at an IOP of 35mmHg (p = 0.151). There was no difference in outflow facility between NPDR1-group and NPDR2-group (0.011 ± 0.048μl/min/mmHg and 0.120 ± 0.059μl/min/mmHg respectively, p = 0.709). CONCLUSIONS: No statistically-significant differences in ocular rigidity and outflow facility could be documented between diabetic patients and controls in this study. No difference in ocular rigidity was detected between mild NPDR and severe NPDR. A trend for lower ocular rigidity in patients with mild NPDR, and a lower 104 Πανεπιστήμιο Κρήτης Τμήμα Ιατρικής Θεονίτσα Δ. Παναγιώτογλου outflow facility in all NPDR patients at 35mmHg may merit further investigation in a bigger sample.
Language	Greek
Subject	Διαβήτης
	Οφθαλμική ακαμψία
Issue date	2018-07-18
Collection	School/Department--School of Medicine--Department of Medicine--Doctoral theses
	Type of Work--Doctoral theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/0/1/e/metadata-dlib-1535798394-493109-16091.tkl
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