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Identifier |
000423713 |
Title |
Crosstalk of inflammation and metabolism : the role of Akt1 kinase |
Alternative Title |
Αλλήλεπίδραση φλεγμονής και μεταβολισμού |
Author
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Παφλιώτη, Ελένη
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Thesis advisor
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Τσατσάνης, Χρήστος
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Abstract |
Inflammatory responses are orchestrated and fine-tuned by a plethora of mechanisms at multiple
levels. Macrophages are important players in innate immunity who can be classically or alternatively
activated and exhibit a pro-inflammatory or an anti-inflammatory phenotype respectively.
Metabolic inflammation is a state of chronic, low-grade inflammation and both immune cells and
adipose tissue are implicated. Excess nutrients provide the primary induction of metabolic inflammation,
while the crosstalk between adipocytes and immune system is what maintains it. There
are several studies exploring the effects of dietary metabolites in inflammation, but their exacts
effects and mechanisms of action in metabolic inflammation are not fully understood. The present
study is focused on studying the effects of gut diet-derived short chain fatty acids on macrophage
polarization and metabolism and identifying Akt1 kinase’s role in this effect, so that it will be
possible to understand macrophage-mediated intestine microbiome alterations in obesity. We also
explore the potential anti-adipogenic effects of terpenoids from sea algae, in the context of adipogenesis
causing/deteriorating metabolic inflammation. Overall, this study adds to the current
knowledge on the regulation of metabolic inflammation by dietary metabolites and the role of Akt1
kinase in it.
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Language |
English |
Subject |
Adidogenesis |
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Macrophages |
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Marine terpenoids |
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Λιπογένεση |
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Μακροφάγα |
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Μεταβολική φλεγμονή |
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Μεταβολισμός |
Issue date |
2019-07-17 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/9/b/c/metadata-dlib-1563796610-775755-6238.tkl
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Views |
213 |