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Identifier

000446043

Title

investigation of signaling pathways implicated in cancer development

Alternative Title

Διερεύνηση σηματοδοτικών μονοπατιών που εμπλέκονται στην εμφάνιση καρκίνου

Author

Καραγιαννάκος, Αλέξανδρος

Thesis advisor

Ζουμπουρλής, Βασίλειος

Reviewer

Σουρβίνος, Γεώργιος
Αγγελάκη, Σοφία

Abstract

Cancer is the second leading cause of death globally. A main hallmark in cancer is the functional deregulation of crucial molecular pathways via driver gene mutations that lead to abnormal gene expression, giving cells a selective growth advantage. Molecular analysis on tissues originated from a wide range of anatomical areas has shown that mutations in different members of several pathways are implicated in different cancer types. In the last decades, significant efforts have been made in order to incorporate this knowledge into the daily medical practice, providing substantial insights towards clinical diagnosis and personalized therapies. However, since there is still a strong need for more effective drug development, a deep understanding of the involved signaling mechanisms and the interconnections between these pathways, is highly anticipated. Here, a systemic analysis on cancer patients of the Pan-Cancer Atlas project was performed, with the aim to select the ten most highly mutated signaling pathways (p53, RTK-RAS, lipids metabolism, PI-3- Kinase/Akt, ubiquitination, b-catenin/Wnt, Notch, cell cycle, homology directed repair (HDR) and splicing) and to provide a detailed description of each pathway’s main deregulation mechanisms, along with corresponding therapeutic applications currently being developed or applied.

Language

English

Subject

Cancer patients

Molecular oncology

Mutations

Precision medicine

Ασθενείς με καρκίνο

Ιατρική ακριβείας

Μεταλλάξεις

Μοριακή ογκολογία

Issue date