Your browser does not support JavaScript!

Home    Search  

Results - Details

Search command : Author="Τρικαλίτης"  And Author="Παντελής"

Current Record: 7 of 68

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Identifier 000452832
Title Μεταλλοφωσφονικές ενώσεις και εφαρμογές στην ελεγχόμενη αποδέσμευση φαρμάκων
Alternative Title Metal-phosphonates and applications on controlled drug delivery systems
Author Βασσάκη, Μαρία Μ
Thesis advisor Δημάδης, Κωνσταντίνος
Reviewer Μήλιος, Κωνσταντίνος
Τρικαλίτης, Παντελής
Νεοχωρίτης, Κωνσταντίνος
Σμόνου, Ιουλία
Στούμπος, Κωνσταντίνος
Turhanen, Petri
Abstract The direct administration of bisphosphonate drugs involves practical limitations, such as low pharmacokinetics and biodistribution, as well as a variety of undesirable side effects. For this reason, several efforts have been made to develop systems in order to achieve their controlled release. Metal-bisphosphonates are a class of compounds made from bisphosphonate ligands, combined with metal ions. Some of their properties render them promising candidates for various applications, such as drug delivery. Bisphosphonates constitute a sub-category of phosphonate compounds. They are drugs for the treatment of diseases associated with disorders of calcium metabolism and, at the same time, have the ability to act as potent ligands for metal centers, due to their phosphonate groups. Thus, they can be combined with various metals of the Periodic Table, forming a variety of crystal structures, such as molecular complexes (0D) or coordination polymers, which, depending on the nature of the metal center and ligand, may form different structural architectures (1D, 2D or 3D). In this doctoral thesis, an investigation was carried out on the coordination chemistry of a large number of bisphosphonate drugs/ligands (1st, 2nd, 3rd, and 4th generation) with divalent alkaline earth metal ions. These synthetic efforts led to the isolation and structural characterization of new biocompatible metal-bisphosphonate compounds. These were evaluated for the release profile of the active ingredients/drugs under different conditions (different pH values or temperature), which simulate the biological conditions of the human body. The aim was to achieve a comprehensive mapping of the controlled release profile of each metal/bisphosphonate system so that structure/activity conclusions can be drawn. Based on these data, it will be possible to determine the potential of these compounds to be used in the future as carriers for drugs against bone-related diseases. Based on the results and the comparison made between them, an attempt was made to clarify the factors that influence the mechanism, the rate and the percentage by which the release of the active ingredient is achieved, as a function of time, i.e. the kinetics of drug release. In this way, they will be a useful tool for the design of "smart" systems for the controlled release of anti-osteoporotic drugs, depending on the needs of each patient. Finally, in vitro cell viability experiments were carried out in order to control the dose/concentration-dependent cytotoxicity of the bisphosphonate drugs in the presence or absence of metal ions.
Language Greek
Subject Bisphosphonate drugs/ligands
Controlled release
Cytotoxicity
Βiocompatible
Βιοσυμβατά
Διφωσφονικά φάρμακα/υποκαταστάτες
Κυτταροτοξικότητα
Issue date 2023-01-18
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/f/d/8/metadata-dlib-1670927349-71519-17608.tkl Bookmark and Share
Views 760

Digital Documents
No preview available

No permission to view document.
It won't be available until: 2026-01-18