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Identifier

000441921

Title

Μελέτη των κυτταρολογικών αλλοιώσεων της επίδρασης ουσιών με ενδοκρινική δράση σε κουνέλια, έπειτα από συνδυαστική και χρόνια έκθεση

Alternative Title

Study of cytological lesions in rabbits after combined and long term exposure to substances with endocrine activity

Author

Σεγρεδάκης, Ιωάννης

Thesis advisor

Τσατσάκης, Αριστείδης
Τσιλιγιάννη, Ιωάννα

Abstract

Aim: The investigation of possible cellular lesions in rabbits after a year combined exposure to the following substances: glyphosate-ROUNDUP, parabens (methyl, propyl and butyl paraben), bisphenol A (BPA) and triclosan (TCS). Material-Methods: Obtained cytological smears using touch prep method from heart, liver, kidneys, thyroid gland and gonads, fixed with 60% ethanol and stained with Pap stain. All these procedures and the estimation of the results were performed in the department of Pathology and Cytology of University General Hospital of Heraklion (PaGNI), using optical microscope ΝΙΚΟΝ Eclypse E400. Results: From the study it emerged that the organs most affected is mainly the thyroid gland in which morphological lesions compatible with papillary neoplasm were detected and the gonads, where for the testicules severe degenerative lesions were observed and in the ovaries, ovarian hyperplasia of the follicular cells. The above alterations justify the role of these substances as “endocrine disruptors”. In the liver was observed glycogenolysis of the hepatic cells, in kidneys presence of cast in the renal tubules, hyperplasia of epithelian cells and evidence of inflammation. Evidence of pericarditis and myocarditis was observed in the heart.

Language

Greek

Subject

Cytological lesions

Glyphosate

Γλυφοσάτη

Δισφαινόλη

Ενδοκρινικοί διαταράκτες

Παραβένες

Issue date

2021-07-29

Collection