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Identifier 000449849
Title Delineating the role of microglia autophagy in autoimmune responses in Multiple Sclerosis
Alternative Title Διερεύνηση του ρόλου της αυτοφαγίας στη μικρογλοία κατά την επαγωγή αυτοάνοσων αποκρίσεων στη Σκλήρυνση κατά Πλάκας
Author Σιδηρόπουλος, Παναγιώτης
Thesis advisor Βεργίνης, Παναγιώτης
Reviewer Χαμηλός, Γεώργιος
Χαραλαμπόπουλος, Ιωάννης
Abstract Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear cellular debris, interact with infiltrating immune cells and secrete soluble factors is essential for maintaining and restoring CNS homeostasis. The autophagic machinery is highly implicated in many aspects of microglia. Dysregulation of autophagy results in accumulation of cellular debris, aggregated proteins and damaged organelles, common hallmarks of neuroinflammation and neurodegenerative diseases, including MS. Furthermore, impaired autophagy could negatively affect antigen-presentation process, due to dysfunctional peptide processing, as well as convert the secretome profile of microglia. Importantly, the crosstalk between autophagy deficient microglia and infiltrating immune cells during EAE course remains undefined. Here, we demonstrate that mice with conditional ablation of autophagic pathway in microglial cells developed less severe EAE which was accompanied by significant accumulation of regulatory T cells in the CNS concomitantly with increased numbers of myeloid-derived suppressor cells suggesting downregulation of inflammation. Thus, we hypothesize that targeting microglial autophagy during the course of MS could endow microglial cells with a “regulatory” phenotype, able to promote disease remission.
Language English
Issue date 2022-07-29
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/e/b/f/metadata-dlib-1657705204-765793-23203.tkl Bookmark and Share
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