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| Identifier |
000376162 |
| Title |
The role of myeloid derived suppressor cells in transplantation and allograft rejection |
| Alternative Title |
Μεταμόσχευση και απόρριψη μοσχεύματος |
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Author
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Lazaridou, Andriana
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Author
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Λαζαρίδου Ανδριάνα.
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Thesis advisor
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Βεργίνης, Παναγιώτης
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Reviewer
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Τσατσάνης, Χρήστος
Μπούμπας, Δημήτριος
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| Abstract |
Transplantation is necessary when disease or injury results in organ failure. The
two major limitations of transplantation in clinical practice are: lack of organ donors
and graft rejection. Immunosuppressive drugs and specific antibodies that promote
graft survival have multiple adverse effects and cause overall dampening of the
immune system. Therefore, novel therapeutic strategies must be discovered.
Regulatory cells play an essential role in transplantation tolerance. T regulatory cells
are instrumental in the maintenance of immunological tolerance. However, both T and
non-T regulatory cells have immunosuppressive properties. Myeloid-derived
suppressor cells (MDSCs) are a heterogeneous population of cells that expands during
cancer, inflammation and infection. These cells are capable of T cell suppression and
immune regulation in the context of various diseases. MDSCs contribute to the
negative regulation of immune responses in cancer patients. Recent observations
suggest that MDSCs contribute to transplantation tolerance and amelioration of graft
vs host disease. MDSCs suppress T, B, and NK proliferation and cytokine production.
Therapeutic targeting and destruction of MDCS is of primary interest in cancer
patients. On the contrary, in transplantation, the therapeutic goal will be to induce,
expand, and activate these cells.
In this study, we examined MDSCs in mice that received fully allogeneic
hematopoietic transplants and skin grafts. MDSCs comprise of two distinct
subpopulations, granulocytic and monocytic MDSCs that may have disparate
functions in disease. For this reason, we investigated the role of each separate
subpopulation in our murine models of transplantation. Furthermore, MDSC
functional suppressive capacity was examined in vitro. We concluded that MDSCs
are vital constituents in the process of graft rejection. They are present during
allogeneic transplantation and obtain the ability to suppress T cell responses in vitro.
Thus, MDSCs may participate in the induction of transplantation tolerance and can
potentially be manipulated for future use in clinical applications.
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| Language |
Greek |
| Subject |
Graft rejection |
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Transplantation |
| Issue date |
2011-07-15 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/e/9/e/metadata-dlib-1351770576-322891-19561.tkl
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| Views |
205 |
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