Your browser does not support JavaScript!

Home    Search  

Results - Details

Search command : Author="Βαμβακάκη"  And Author="Μαρία"

Current Record: 20 of 72

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Identifier 000443891
Title Photo- and acid-degradable polyacylhydrazone–doxorubicin conjugates for controlled anticancer drug delivery
Alternative Title Σύνθεση και χαρακτηρισμός συζευγμένων πολυακυλο-υδραζονών - δοξορουβικίνης, διασπώμενων με φως και pH για την ελεγχόμενη απελευθέρωση αντικαρκινικών φαρμάκων
Author Κοθρή, Μάρθα Γεωργία
Thesis advisor Προυσής, Κυριάκος
Reviewer Βαμβακάκη, Μαρία
Καλογεροπούλου, Θεοδώρα
Abstract Cancer is the second leading cause of death worldwide for both men and women and attacks even the very young ages. In the recent years, significant progress has been made on the development of pharmaceuticals for the treatment of cancerous tumors. However, the significant side effects of their conventional route of administration, i.e., the non-selective and uncontrolled delivery to cancer tissues, have driven the need for controlled drug delivery systems. Drug delivery systems can safely deliver a drug substance by combining a suitable material with bioactive molecules or drugs that would otherwise have inadequate activity or undesirable pharmacokinetic characteristics or would be toxic to healthy normal cells. Polymeric drug delivery systems that have been investigated range from polymeric micelles, vesicles, hydrogels, etc. The aim of this thesis is to report the synthesis and characterization of a new, linear, main-chain photoand acid-degradable copolymer based on acylhydrazone linkages. The polymer synthesis was carried out by the step-growth copolymerization of adipic acid dihydrazide with a bifunctional poly (ethylene glycol) bearing benzaldehyde end-groups, under mild acidic conditions, to afford hydrophilic PEG-alt-adipic acid (PEG-alt-AA) alternating copolymers. The synthesized polymers were characterized by size exclusion chromatography, proton nuclear magnetic resonance and attenuated total reflection-Fourier transform infrared spectroscopies. The main-chain photo- and acid-induced degradation of the copolymers in dimethylsulfoxide and water, respectively, to produce the two precursor comonomers, was verified by UV-vis spectroscopy at light intensities as low as 0.1 mW cm−2 at λ = 254 nm. Next, a model anticancer drug, doxorubicin (DOX), was chemically linked to the polymer chain end(s) via acylhydrazone bond(s), resulting in amphiphilic PEG-alt-adipic acid-DOX (PEG-alt-AA-DOX) polymer–drug conjugates. The conjugates were self-assembled in water to form spherical nanoparticles, as evidenced by scanning and transmission electron microscopies and dynamic light scattering. The irradiation of the selfassembled PEG-alt-AA-DOX conjugates with UV light and the simultaneous decrease of the solution pH resulted in the disruption of the assemblies, due to the combined photolysis and acidolysis of the acylhydrazone bonds, and led to the controlled release of the therapeutic cargo.
Language English
Subject Polymer -drug conjugates
Πολυμερή που διασπώνται με φως και PH
Συζευγμένα συστήματα πολυμερών -φαρμάκων
Συστήματα μεταφοράς φαρμάκων
Issue date 2021-12-01
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/b/d/6/metadata-dlib-1640004925-918381-28262.tkl Bookmark and Share
Views 220

Digital Documents
No preview available

Download document
View document
Views : 0