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Identifier 000413417
Title Απομόνωση και χαρακτηρισμός συστατικών από το φυτό Phlomis × commixta Rech. f. (P. cretica × P. lanata)
Alternative Title Isolation and identification of components from plant Phlomis × commixta Rech. f. (P. cretica × P. lanata)
Author Στεφανάκης, Μιχαήλ Κων
Thesis advisor Κατερινόπουλος, Χαράλαμπος
Reviewer Στεφάνου, Ευριπίδης
Βασιλικογιαννάκης, Γεώργιος
Στρατάκης, Εμμανουήλ
Σπύρος, Απόστολος
Πυρίντσος, Στέργιος
Λάζαρη, Διαμάντω
Abstract The present research paper includes the analysis of the components of the P. × commixta hybrid, a plant of the genus Phlomis. The plant under study was separated into flowers, leaves and roots. The secondary metabolites of the plant were recovered via extractions, isolated by various chromatographic techniques such as V.L.C., C.C., HPLC, and identified by spectroscopic methods such as UV / Vis, NMR, GC-MS and LC-MS. The compounds isolated from the flowers were a) flavonoids: naringenin, eriodyctiol, luteolin, apigenin-7-O-β-D-glucoside, eriodyctiol-7-O-β-D-glucoside, diosmentin-7-O-β-D-glucoside; b) phenylethanoic glycosides: martinoside, verbascoside, forsithoside B; c) a chromone: 5,7-dihydroxychromone; d) phenolic acids: caffeic acid, p-hydroxybenzoic acid, chlorogenic acid, chlorogenic acid methyl ester, gallic acid, p-coumaric acid and e) a aliphatic hydrocarbon: Docos-1-ene. From the leaves were identified a) flavonoids: quercetin, apigenin, hesperetin, luteolin-7-O-β-D-glucoside, quercetine-3-O-β-D-glucoside; b) phenylethanoid glycosides: echinacoside, verbascoside, forcythoside B; c) a phenolic acid: vanillic acid and d) a glycoside of allylic alcohol: 3-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosyl-oct-1-ene-3-ol which was fully characterized as natural product for the first time. From the roots of the plant were isolated a) metabolites of the phenylethanoid glycoside class: allysonoside, verbascoside, forsythoside B; b) steroids: brassicasterol and stigmasterol and c) tyrosol esters: tyrosol lignoserate and tyrosol methyl ether palmitate, the latter one being isolated as a natural product for the first time. Although Phlomis species thrive almost all over the world, the present work is the first report on the ingredients of the P. × commixta hybrid. The pharmaceutical profile of the components isolated from the hybrid is in agreement with the folklore medicine applications reported in the literature, and is indicative of the potential use of the plant in contemporary medicine.
Language Greek
Subject Flavonoids
P. × commixta
Phenolic Derivatives
Phenylethanoid Glycosides
Secondary Metabolites
Steroids
Tyrosol Esters
Δευτερογενείς Μεταβολίτες
Στεροειδή
Τυροσολικοί εστέρες
Φαινολικά παράγωγα
Φαινυλοαιθανοειδείς γλυκοζίτες
Φλαβονοειδή
Issue date 2017-12-19
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Chemistry--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/4/5/e/metadata-dlib-1513772332-717370-10985.tkl Bookmark and Share
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