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Title |
Synthesis of carboxylated chitosan derivatives for tissue engineering applications |
Author
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Τσάμπαλλας Βασίλειος
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Thesis advisor
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Βαμβακάκη, Μαρία
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Abstract |
Chitosan, a partially deacetylated derivative of a natural polysaccharide, chitin, is
one of the most popular biomaterials, due its excellent biocompatibility,
biodegradability and strong antimicrobial properties. However, it has limited
solubility at pH values close to neutral pH, because of its very stable crystalline
structure arising from strong inter- and intra-molecular hydrogen bonds. The
conversion of chitosan into a water-soluble form can be achieved using different
methods. One such modification approach, focuses on the addition of carboxymethyl
groups onto either its amino (C2-NH2) or its hydroxyl (3-OH, 6-OH) groups or even
onto both of these groups simultaneously.
In this bachelor thesis, a series of different carboxylated chitosan derivatives
modified either through its amino, hydroxyl or both side-groups, with different
degrees of modification were prepared. The synthesized samples of modified chitosan
were characterized by Fourier-transform infrared (FTIR) and nuclear magnetic
resonance (NMR) spectroscopies and thermogravimetric analysis (TGA). These
materials will be employed to investigate the effect of the specific functionalization of
the chitosan side-groups on its biological properties in tissue engineering
applications
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Language |
Greek |
Issue date |
2021-11-26 |
Collection
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School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Graduate theses
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Type of Work--Graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/8/a/a/metadata-dlib-1642074506-198668-587.tkl
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Views |
368 |