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Identifier 000451097
Title Scaffolding techniques and tissue imaging on them
Alternative Title Τεχνικές κατασκευής ικριωμάτων και απεικόνηση ιστού σε αυτά
Author Δασκαλάκης, Παναγιώτης
Thesis advisor Στρατάκης, Εμμανουήλ
Abstract Regenerative medicine and tissue engineering have recently been a trending scientific field in the world of modern medicine. The future of tissue engineering is highly promising offering solutions for successful transplantation, repair, regeneration, and self-healing of tissue, organoids, and organs. 3D printing is a promising technique used as a fabrication methods in creating scaffolds for tissue engineering. Great advantages using the 3D printing technique are proved to be in creating complex geometries, gradient porosities, and co-culture of numerous cells, using well-developed biomaterials. Thus, these applications are limited caused of the low variety in biomaterials and construction mechanisms that are used yet. The purpose of this thesis research is the conversion of a standardized 3D printer to an ultra-low-cost 3D-4D bioprinter (constructed from PLA 3D printed parts), and the construction of 3D-4D scaffolds for cellular responses such as adhesion and proliferation. Cellulose acetate is the chosen bioink for the bioprinted structure because of the flexible printability of the mixture and the high mechanical properties, Cellulose Acetate offers. Parametric calculations for the extrusion manipulation are presented in boards, and firmware commands that had to be changed for temperature safety factors (fluid and not fused material) are presented as well. 3D scaffolds were designed and developed into Gcode files for the bioprinter to fabricate, delivering high-quality bioprinted scaffolds after modification of the printing parameters, bioprinting-mechanism, and bioink composition. The results showed that the CA scaffolds created from the converted bioprinter offered a better geometrical structure and resolution compared to other printed scaffolds. Future research is focused on the development of advanced bioinks, more accurate geometrical modeling, and in-vitro cytocompatibility studies.
Language English, Greek
Subject Bio-ink
Tissue engineering
Βιο-εκτύπωση
Βιο-μεθάνη
Μηχανική ιστών
Issue date 2022-07-29
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/5/8/0/metadata-dlib-1663571551-310133-30690.tkl Bookmark and Share
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