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Identifier	000413417
Title	Απομόνωση και χαρακτηρισμός συστατικών από το φυτό Phlomis × commixta Rech. f. (P. cretica × P. lanata)
Alternative Title	Isolation and identification of components from plant Phlomis × commixta Rech. f. (P. cretica × P. lanata)
Author	Στεφανάκης, Μιχαήλ Κων
Thesis advisor	Κατερινόπουλος, Χαράλαμπος
Reviewer	Στεφάνου, Ευριπίδης Βασιλικογιαννάκης, Γεώργιος Στρατάκης, Εμμανουήλ Σπύρος, Απόστολος Πυρίντσος, Στέργιος Λάζαρη, Διαμάντω
Abstract	The present research paper includes the analysis of the components of the P. × commixta hybrid, a plant of the genus Phlomis. The plant under study was separated into flowers, leaves and roots. The secondary metabolites of the plant were recovered via extractions, isolated by various chromatographic techniques such as V.L.C., C.C., HPLC, and identified by spectroscopic methods such as UV / Vis, NMR, GC-MS and LC-MS. The compounds isolated from the flowers were a) flavonoids: naringenin, eriodyctiol, luteolin, apigenin-7-O-β-D-glucoside, eriodyctiol-7-O-β-D-glucoside, diosmentin-7-O-β-D-glucoside; b) phenylethanoic glycosides: martinoside, verbascoside, forsithoside B; c) a chromone: 5,7-dihydroxychromone; d) phenolic acids: caffeic acid, p-hydroxybenzoic acid, chlorogenic acid, chlorogenic acid methyl ester, gallic acid, p-coumaric acid and e) a aliphatic hydrocarbon: Docos-1-ene. From the leaves were identified a) flavonoids: quercetin, apigenin, hesperetin, luteolin-7-O-β-D-glucoside, quercetine-3-O-β-D-glucoside; b) phenylethanoid glycosides: echinacoside, verbascoside, forcythoside B; c) a phenolic acid: vanillic acid and d) a glycoside of allylic alcohol: 3-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosyl-oct-1-ene-3-ol which was fully characterized as natural product for the first time. From the roots of the plant were isolated a) metabolites of the phenylethanoid glycoside class: allysonoside, verbascoside, forsythoside B; b) steroids: brassicasterol and stigmasterol and c) tyrosol esters: tyrosol lignoserate and tyrosol methyl ether palmitate, the latter one being isolated as a natural product for the first time. Although Phlomis species thrive almost all over the world, the present work is the first report on the ingredients of the P. × commixta hybrid. The pharmaceutical profile of the components isolated from the hybrid is in agreement with the folklore medicine applications reported in the literature, and is indicative of the potential use of the plant in contemporary medicine.
Language	Greek
Subject	Flavonoids
	P. × commixta
	Phenolic Derivatives
	Phenylethanoid Glycosides
	Secondary Metabolites
	Steroids
	Tyrosol Esters
	Δευτερογενείς Μεταβολίτες
	Στεροειδή
	Τυροσολικοί εστέρες
	Φαινολικά παράγωγα
	Φαινυλοαιθανοειδείς γλυκοζίτες
	Φλαβονοειδή
Issue date	2017-12-19
Collection	School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses
	Type of Work--Doctoral theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/4/5/e/metadata-dlib-1513772332-717370-10985.tkl
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