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Identifier 000456741
Title Συστήματα υποστήριξης αποφάσεων στη χρήση φαρμακευτικών φυτών και φυτικών παραγώγων της παραδοσιακής ιατρικής : ασφάλεια, αλληλεπιδράσεις, ανεπιθύμητες ενέργειες
Alternative Title Decision support system for the use of medicinal plants and plant extracts of traditional medicine: safety, interactions, undesirable effects
Author Λαϊνά, Δανάη Γ.
Thesis advisor Πυρίντσος, Στέργιος
Reviewer Κοτζαμπάσης, Κυριάκος
Καλαντίδης, Κρίτων
Abstract Background: The use of herbal medicines for therapeutic purposes is welldocumented throughout human history. The recent resurgence of interest of plant remedies, either as herbal preparations either as dietary supplements, in combination with the lack of accurate legal frameworks by the regulatory authorities has raised concerns about their safety. Aims of the study: This study aims to contribute in the development of a decision support system for the selection and consequently for the use of medicinal plants and their extracts which are used in traditional medicine, with respect to their safety, the drug – herb interactions and the reported undesirable effects. Specifically, we suggest a consistent methodology/process for the generation of a valid safety fingerprinting for each use of a medicinal plant or plant preparation, which in turn could lead to the creation of a safety barcode. Methodology: The methodology includes a data mining approach, using a series of datasets extracted from various information systems, and data migration in a system of partial order and recursive partitioning, which has led to the construction of decision trees, the generation of safety fingerprinting and safety barcoding. Results: The overlaps among the information systems used in this study concerning medicinal plants, were not particular high. Although, the majority of medicinal plants is considered to be safe and without recorded drug – herb interactions, the undesirable effects is also an important part which completes their safety profile. The decision trees’ structure includes all the paths needed for the decision making process in the selection and the use of the appropriate medicinal plant whereas partial order system could be a complementary tool for the selection. Therefore, each plant is characterized by a unique safety code in the sense of barcode. Conclusions: The safety of medicinal plants is a complicated issue, which may include a series of different factors. The system suggested in this study, considers the available information in a user friendly mode. An important external limitation of the study is the lack of frequencies concerning the undesirable effects, implying also the respective lack in the current pharmacovigilance systems. Nevertheless, the suggested system is in accordance with the new policies of important organizations such as FDA and WHO and in case of implementation it could cover fundamental needs of the health practitioners.
Language Greek
Issue date 2017-03-17
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/0/3/b/metadata-dlib-1687948150-592283-673.tkl Bookmark and Share
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