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Identifier

000423713

Title

Crosstalk of inflammation and metabolism : the role of Akt1 kinase

Alternative Title

Αλλήλεπίδραση φλεγμονής και μεταβολισμού

Author

Παφλιώτη, Ελένη

Thesis advisor

Τσατσάνης, Χρήστος

Abstract

Inflammatory responses are orchestrated and fine-tuned by a plethora of mechanisms at multiple levels. Macrophages are important players in innate immunity who can be classically or alternatively activated and exhibit a pro-inflammatory or an anti-inflammatory phenotype respectively. Metabolic inflammation is a state of chronic, low-grade inflammation and both immune cells and adipose tissue are implicated. Excess nutrients provide the primary induction of metabolic inflammation, while the crosstalk between adipocytes and immune system is what maintains it. There are several studies exploring the effects of dietary metabolites in inflammation, but their exacts effects and mechanisms of action in metabolic inflammation are not fully understood. The present study is focused on studying the effects of gut diet-derived short chain fatty acids on macrophage polarization and metabolism and identifying Akt1 kinase’s role in this effect, so that it will be possible to understand macrophage-mediated intestine microbiome alterations in obesity. We also explore the potential anti-adipogenic effects of terpenoids from sea algae, in the context of adipogenesis causing/deteriorating metabolic inflammation. Overall, this study adds to the current knowledge on the regulation of metabolic inflammation by dietary metabolites and the role of Akt1 kinase in it.

Language

English

Subject

Adidogenesis

Macrophages

Marine terpenoids

Λιπογένεση

Μακροφάγα

Μεταβολική φλεγμονή

Μεταβολισμός

Issue date

2019-07-17