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Identifier

000421105

Title

Σύνθεση και μελέτη νανοϋβριδιών με στοιχεία λανθανιδών για φαρμακευτική χρήση

Alternative Title

Synthesis and study of lanthanide nanohybrids for pharmaceutical use

Author

Σταυρινού, Θεοδώρα Α.

Thesis advisor

Γανωτάκης, Δημήτριος

Reviewer

Τσιώτης, Γεώργιος
Χανιωτάκης, Νικόλαος

Abstract

In the present study, magnetic nanoparticles with perspective applications in MRI and drug delivery were prepared. Nano-hybrids with lanthanide elements were synthesized. More specifically, layered structures of gadolinium nanoparticles with compensating nitrate anions ( GdDy-NO₃ ) and gadolinium, dysprosium, terbium with compensating nitrate anions ( GdDyTb-NO₃ ) were prepared and extensively characterized by using X-ray diffraction, infrared spectroscopy, passing electron microscopy and fluorescence microscopy. Various nanohybrids were prepared by using an ion exchange method. In particular, the amino acids aspartic acid, alanine, glutamine, glycine, cysteine and threonine were successfully incorporated into the GdDy-NO₃ nanoparticles. After the successful addition of simple amino acids, the dipeptide L-Ala-Gln, a pharmaceutical compound that acts topically in the gastrointestinal tract, and nitrofurantoin, an antibiotic used for urinary tract infections as well as valproic acid, belonging to antiepileptic drugs, were also incorporated in the nanoparticles. GdDyTb-NO₃ nanoparticles were also used for the development of nanohybrids. More specifically, glutamic acid, histidine and the aromatic amino acids phenylalanine and tyrosine were successfully incorporated into the GdDyTb-NO₃ nanoparticles by using the ion exchange method. In addition to the ion exchange method, nanohybrids were also prepared by using a delamination procedure. The dipeptide L-Ala-Gln was added to the GdDy-NO₃ and glutamic acid incorporated in the GdDyTb-NO₃ nanoparticles by using this particular method. In order to develop nanohybrids with a tumor cell targeting ability, the surface of the GdDy-NO₃ nanoparticles was modified with amino groups and subsequently with folic acid. Such nanoparticles could be loaded with an anticancer drug and directed to tumor cells that overexpress folic acid receptors.

Language

Greek

Subject

Anion exchange

Delamination

Layered double hydroxides

Targeted drug delivery

Ανιοανταλλαγή

Αποστοίβαξη

Στοιβαγμένα διπλά υδροξείδια

Στοχευμένη χορήγηση φαρμάκων

Issue date