E-Locus - Institutional Repository of the University of Crete

Home Search

Results - Details

Search command : Author="Βόντας" And Author="Ιωάννης"

Current Record: 52 of 76

[Add to Basket]

Identifier

000398753

Title

Characterization of Stitcher-Cadherin 96Ca and the transcription factor Grainyhead-Grh in Anopheles gambiae

Alternative Title

Χαρακτηρισμός του Στίτσερ-Καντερίνη 96Ca και του μεταγραφικού παράγοντα Γκρέινιχεντ-Grh στον Ανωφελή κώνωπα

Author

Σπανού, Χαρίκλεια Ε.

Thesis advisor

Siden-Kiamos, Inga

Reviewer

Τζαμαρίας, Δημήτριος
Βόντας, Ιωάννης

Abstract

Malaria is a deadly infectious disease caused by the parasitic protozoo Plasmodium that cost the lives of nearly 438,000 people in 2015 alone. Due to the current socioeconomic situation, an approach that addresses the problem more globally needs to be employed. To that end, much attention has received the study of malaria transmission through the mosquito host. New findings could help elucidate the mechanisms involved in mosquito host defense that could subsequently be utilized in downstream applications to limit disease propagation through the mosquitoes. When an Anopheline mosquito ingests infected blood, the parasite is taken up and then fertilization takes place in the mosquito midgut where the resulting zygote proceeds to the next developmental stage, the ookinete. The ookinete traverses the midgut epithelium by penetrating 1-2 midgut cells in the process that then undergo apoptosis. In that way, the parasite wounds the midgut epithelium. Recently, a wound-healing mechanism has been dissected when Drosophila melanogaster embryos are subject to aseptic injury. In this signaling cascade, Stitcher, the receptor, receives the stress signals that are then transduced to intermediate kinases that activate Grainyhead tο drive the transcription of barrier repair genes. In this work, it was investigated whether the homologous proteins in Anopheles gambiae midgut signal for a similar response during and right after ookinete traversal.

Language

English

Subject

Cad96Ca/Stitcher

Malaria

Wound-healing

Ανωφελής

Ελονοσία

Επούλωση τραύματος

Issue date

2016-03-18

Collection