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Identifier 000349404
Title Ανίχνευση του κυτταρομεγαλοϊού (CMV) σε αθηρωματικές πλάκες και συσχέτιση με την αιτιοπαθογένεια της νόσου
Author Ξενάκη, Ευαγγελία Γ
Thesis advisor Σπαντίδος, Δημήτριος
Reviewer Βάρδας, Παναγιώτης
Σαμώνης, Γεώργιος
Abstract Several studies have reported an association between infectious agents and atherosclerosis. Cytomegalovirus (CMV) is the most commonly implicated viral pathogen. However, the role of cytomegalovirus in atherosclerosis remains obscure. In the present study, we evaluated the presence of cytomegalovirus DNA in atherosclerotic plaques and normal vessel walls. Forty arterial specimens from coronary plaques and 27 samples from normal vessels were obtained from 26 patients who underwent aortocoronary bypass surgery. The specimens were analyzed by polymerase chain reaction for the presence of the cytomegalovirus immediate early genomic region. Cytomegalovirus DNA was detected in 9 out of 26 patients (34.6%). Viral DNA was detected in both non-atherosclerotic tissues and atherosclerotic plaques. No statistically significant differences were observed between normal and diseased vessels. A similar lack of statistical association was observed between the presence of CMV and clinical parameters such as arterial hypertension, diabetes mellitus, smoking or hypercholesterolemia. Our findings, in accordance with previous studies, do not support a direct causative role of CMV in the development of atherosclerotic plaques.
Language Greek
Subject Atherosclerosis
Cytomegalovirus
Αθηρωσκλήρωση
Issue date 2008-12-15
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/0/1/0/metadata-dlib-7cb3e9f107b7c012d5a4345360a16b84_1252061201.tkl Bookmark and Share
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