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Identifier |
000349404 |
Title |
Ανίχνευση του κυτταρομεγαλοϊού (CMV) σε αθηρωματικές πλάκες και συσχέτιση με την αιτιοπαθογένεια της νόσου |
Author
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Ξενάκη, Ευαγγελία Γ
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Thesis advisor
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Σπαντίδος, Δημήτριος
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Reviewer
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Βάρδας, Παναγιώτης
Σαμώνης, Γεώργιος
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Abstract |
Several studies have reported an association between infectious agents and
atherosclerosis. Cytomegalovirus (CMV) is the most commonly implicated viral
pathogen. However, the role of cytomegalovirus in atherosclerosis remains obscure.
In the present study, we evaluated the presence of cytomegalovirus DNA in
atherosclerotic plaques and normal vessel walls. Forty arterial specimens from
coronary plaques and 27 samples from normal vessels were obtained from 26 patients
who underwent aortocoronary bypass surgery. The specimens were analyzed by
polymerase chain reaction for the presence of the cytomegalovirus immediate early
genomic region. Cytomegalovirus DNA was detected in 9 out of 26 patients (34.6%).
Viral DNA was detected in both non-atherosclerotic tissues and atherosclerotic
plaques. No statistically significant differences were observed between normal and
diseased vessels. A similar lack of statistical association was observed between the
presence of CMV and clinical parameters such as arterial hypertension, diabetes
mellitus, smoking or hypercholesterolemia. Our findings, in accordance with previous
studies, do not support a direct causative role of CMV in the development of
atherosclerotic plaques.
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Language |
Greek |
Subject |
Atherosclerosis |
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Cytomegalovirus |
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Αθηρωσκλήρωση |
Issue date |
2008-12-15 |
Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
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Type of Work--Doctoral theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/0/1/0/metadata-dlib-7cb3e9f107b7c012d5a4345360a16b84_1252061201.tkl
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Views |
293 |