Results - Details
Search command : Author="Γανωτάκης"
And Author="Δημήτριος"
Current Record: 10 of 101
|
Identifier |
000460496 |
Title |
Σύνθεση, χαρακτηρισμός και μελέτη βιολογικής δραστικότητας παραγώγων της αλαντολακτόνης και ισοαλαντολακτόνης, συστατικών που απομονώθηκαν από το φυτό Inula helenium |
Alternative Title |
Synthesis, characterization and biological activity study of alantolactone and isoalantolactone analogues, components isolated from the plant Inula helenium |
Author
|
Παπαστεφανάκη, Ευγενία Ε.
|
Thesis advisor
|
Γανωτάκης, Δημήτριος
|
Reviewer
|
Νεοχωρίτης, Κωνσταντίνος
Σπύρος, Απόστολος
|
Abstract |
The species Inula helenium belongs to the genus Inula (Asteraceae) and is being
used in traditional medicine until today, mainly for the cure of respiratory problems and
skin diseases, due to its antibacterial and anti-inflammatory properties. According to
studies, the strong bioactivity of the plant is attributed to the eudesmanolides which
contains, and mainly to the alantolactone (1) and isoalantolactone (6). That was the
main incentive for the isolation of the compounds, which were obtained in high purity
after extractions of the plant’s dried roots and application two separate isolation
techniques. The isolation took place either after multiple column chromatography
separations or after repeated recrystallization. During this procedure, two more
secondary metabolites from the eudesmanolide class were isolated and they were found
structurally similar to the aforementioned compounds, namely 11,13-dihydroalantolactone (11) and 11,13-dihydro-isoalantolactone (12). Besides the isolation of the
natural components, the modification of their structure was considered as necessary for
the structure-activity relationship studies and biological tests. Thus, each compound
was derivatized as its nitrile, the corresponding acid, as well as its azide derivative and
the corresponding amine. The secondary metabolites and their derivatives were
characterized via NMR spectroscopy, GC-MS and HRMS. Lastly, antioxidant studies
were conducted on compounds 1, 6, their derivatives and on the methanolic and hexane
plant extracts, through the method of the DPPH radical. The study revealed a strong
antioxidant capacity of the methanolic extract and a moderate antioxidant activity of
alantolactone amine 5a. Similar studies are underway in our laboratory.
|
Language |
Greek |
Subject |
Antioxidants |
|
Secondary metabolites |
|
Synthetic derivatives |
|
Αντιοξειδωτικά |
|
Δευτερογενείς μεταβολίτες |
|
Συνθετικά παράγωγα |
Issue date |
2023-11-23 |
Collection
|
School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
|
|
Type of Work--Post-graduate theses
|
Permanent Link |
https://elocus.lib.uoc.gr//dlib/5/8/0/metadata-dlib-1700644748-940984-8837.tkl
|
Views |
934 |
Digital Documents
|
|
No permission to view document.
It won't be available until: 2025-11-23
|