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Identifier 000367216
Title Επίδραση της προποφόλης στην εμφάνιση περιοδικής αναπνοής σε ασθενείς με εγκεφαλική βλάβη
Alternative Title Effect of propoful on breathing stability in adult ICU patients with brain damage
Author Κλημαθιανάκη, Μαρία
Thesis advisor Γεωργόπουλος, Δημήτρης
Reviewer Σιαφάκας, Νικόλαος
Τζανάκης, Νικόλαος
Ασκητοπούλου, Ελένη
Κονδύλη Ευμορφία
De Bree Eelco
Παπαιωάννου Αλεξία
Abstract Background: To investigate Propofol’s effect on breathing stability of brain damage patients, as quantified by the Loop Gain (LG) of the respiratory system (breathing stability increases with decreasing LG). Methods: In 11 stable brain damage patients full polysomnography was performed before, during and after propofol sedation, titrated to achieve stage 2 or slow wave sleep. During each period, patients were ventilated with proportional assist ventilation and the % assist was increased in steps, until either PB occurred or the highest assist (95%) was achieved. The tidal volume amplification factor (VTAF) at the highest assist level reached just before PB occurred was used to calculate LG (LG=1/VTAF). Results: In all but one patients PB was observed with increasing the % assist. With propofol the assist level at which PB occurred (73±19%) was significantly higher, than that before (43±35%) and after propofol sedation (49±29%). As a result, with propofol LG (0.49±0.2) was significantly lower than that before (0.74±0.2) and after propofol sedation (0.69±0.2) (p΄&λτ 0.05). Conclusions: 1) Patients with brain damage are at risk of unstable breathing, as indicated by a high and reproducible LG, and 2) propofol infusion results in a significant decrease in LG, suggesting that its overall effect on control of breathing is stabilizing.
Language Greek
Subject Brain injury
Control of breathing
Periodic breathing
Respiratory system
Έλεγχος αναπνοής
Εγκεφαλική βλάβη
Περιοδική αναπνοή
Issue date 2010-07-20
Collection   Faculty/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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