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Identifier 000416553
Title Βιοκαταλυτικές αναγωγές α-μεθοξυ-β-κετοεστερών
Alternative Title Biocatalytic reductions of α-methoxy-β-ketoesters
Author Ζωίδη, Μαργαρίτα
Thesis advisor Σμόνου, Ιουλία
Reviewer Κατερινόπουλος, Χαράλαμπος
Στρατάκης, Εμμανουήλ
Abstract Biocatalysis has been established as a tool of Green Chemistry because of the advantages that enzymes, used as catalysts, offer, compared to other common chemical catalysts. Their chemο-, regio-, but mostly, their stereoselectivity, make enzymes very useful for organic chemists as far as chiral synthesis or pharmateutical progress is concerned. In this project the enzymes that have been used as catalysts are ketoreductases. Their natural role is the reduction of ketones or some aldehydes to the corresponding chiral alcohols. The synthesis of six substrates in the form of alkyl α-methoxy-β-ketoesters, and also, the study of catalytic activity and selectivity of ketoreductases on these substrates, is presented. The relative configuration of the products has been determined by nuclear magnetic resonance (NMR), gas chromatography (GC) and high-performance liquid chromatography (HPLC), as well as the catalytic activity and selectivity of ketoreductases towards these specific substrates.
Language Greek
Subject Biocatalysis
Issue date 2018-07-18
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
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