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Identifier 000416044
Title Παράγωγα του EGTA ως φθορίζοντες δείκτες κατιόντων : σύνθεση και φθορισμομετρικά χαρακτηριστικά
Alternative Title EGTA derivatives as fluorescent cation sensors: synthesis and fluorescence spectral properties
Author Φίλιππα, Ιωάννα Κ.
Thesis advisor Κατερινόπουλος, Χαράλαμπος
Reviewer Στρατάκης, Εμμανουήλ
Σμόνου, Ιουλία
Abstract Ιn this thesis the synthesis and spectroscopic profile studies of a series of potential fluorescent ion indicators is described. The ionophores embedded in these indicators are analogues of the known Ca2+ chelator EGTA (ethylene glycol bis (b-aminoethyl ether) -N,N,N',N'-tetraacetic acid) and in particular the "di-substituted" derivative EGDA, (ethylene glycol bis (b-aminoethyl ether) -N,N',-diacetic acid) and "tri-substituted" derivative EGTRA, (ethylene glycol bis (b-aminoethyl ether) -N,N,N',-triacetic acid). The embedded chromophores are substituted coumarins, a known class of chromophores used in the preparation of fluorescent probes. When the ionophore is linked to the coumarin chromophore via a conjugated system - in this case an amide bond - then the response is usually that of a ratiometric sensor, based on fluorescence ratio measurements. When this conjugation is interrupted, or when the chelated ion is not coordinated with the chromophore, the probe response is expected to be that of a “turn-on” sensor and measurements are based on the increase of fluorescence intensity. Changes in the chelating moiety of the molecule led to changes in the selectivity of the sensors to the ions under study while mode of coordination of the ions to the indicators influenced their fluorometric response.
Language Greek
Subject Probes heavy metals
Βαρέα μέταλλα
Issue date 2018-07-18
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
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