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Identifier 000448423
Title Μελέτη αποφυλλοποίησης και επαναστοίβαξης ανόργανων μητρών LDH (Στοιβαγμένων Διπλών Υδροξειδίων) με χρήση στη στόχευση φαρμάκων
Alternative Title A study of the exfoliation and restacking of LDH (Layered Double Hydroxide) inorganic matrices with use in drug targeting
Author Σφενδουράκης, Γεώργιος - Παναγιώτης Κ.
Thesis advisor Γανωτάκης, Δημήτριος
Reviewer Τσιώτης, Γεώργιος
Χανιωτάκης, Νικόλαος
Βαμβακάκη, Μαρία
Παυλίδης, Ιωάννης
Σπύρος, Απόστολος
Ελευθεριάδης, Νικόλαος
Abstract The aim of this thesis was the synthesis of bioinorganic complexes, developed through the entrapment of organic substances inside layered double hydroxides. A plethora of molecules with biologic applications was examined, with emphasis on amino acids and deoxyribonucleic acid, while at the same time alterations to the inorganic matrix with the purpose of improving its capacity were investigated. The successful synthesis of layered double hydroxides, composed of magnesium and aluminum in a 2 to 1 ratio, is described. The inorganic matrix was then used to entrap anions of ascorbate, lactate, acetate and cholate, as well as the drug nitrofurantoin. These nanobiohybrids were characterized by x-ray diffraction (XRD) and infrared spectroscopy (IR). The exfoliation of layered double hydroxides through two new methods was examined, more specifically through sonication of the matrix dissolved in glycerol or propyleneglycol. These methods were subsequently compared to the most efficient already established methods of exfoliation. The exfoliation was confirmed through dynamic light scattering and liquid x-ray diffraction (liquid XRD), and was followed by examination of its stability, which showed that the new solvents have a better exfoliation profile than those established in the literature. The above techniques were then used to insert molecules inside layered double hydroxides through restacking. This method was investigated as an alternative to the expensive coprecipitation, which is widely used to insert molecules, such as amino acids. By using restacking, 16 LDH nanobiohybrids containing amino acids were then synthesized and compared to similar ones prepared by anion exchange. The results were compared to those in the literature, and it was demonstrated that restacking has advantages over other methods of synthesizing LDH nanobiobrids and could lead to successful synthesis in experiments where anion exchange could not be used. In addition, through these experiments, problems in the purification processes that are usually developed during LDH synthesis are highlighted, emphasizing the importance of the medium used during the purification process and how this affects the final nanobiobrid. Finally, the advantage of the increased active surface of the exfoliated LDH and subsequent restacking was examined in order to insert molecules that cannot easily be inserted because of their size, such as deoxyribonucleic acid.
Language Greek
Subject Acetic acid
Amino acids
Ascorbic acid
Cholic acid
Deoxyribonucleic acid (DNA)
Drug delivery
Lactic acid
Layered double hydroxides (LDH)
Nanobiohybrids
Nitrofurantoin
Αμινοξέα
Αποφυλλοποίηση
Ασκορβικό οξύ
Γαλακτικό οξύ
Δεοξυριβονουκλεϊκό οξύ (DNA)
Επαναστοίβαξη
Μεταφορά φαρμάκων
Νανοβιοϋβρίδια
Νιτροφουραντοΐνη
Οξικό οξύ
Στοιβαγμένα διπλά υδροξείδια (LDH)
Χολικό οξύ
Issue date 2022-06-07
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/d/8/2/metadata-dlib-1653125973-385870-10710.tkl Bookmark and Share
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