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| Identifier |
000447619 |
| Title |
Συμπεριφορικές μελέτες κινητικότητας και μνήμης σε διαγονιδιακά GLUD2 ζώα |
| Alternative Title |
Behavioral studies of mobility and memory in transgenic GLUD2 animals |
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Author
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Φραγκιαδάκη, Ειρήνη
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Thesis advisor
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Σπανάκη, Κλεάνθη
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Reviewer
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Ζαγανάς, Ιωάννης
Σιδηροπούλου, Κυριακή
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| Abstract |
Intelligence and great abilities that characterize the human brain have been studied
extensively. Human evolution is characterized by structural brain expansion and upregulation
of genes that participate in energy metabolism and synaptic transmission, with the
glutaminergic signaling playing a crucial role. Binding of glutamate on its receptors mediates
molecular signaling pathways in the brain that transform synaptic plasticity, which is an
important feature of neuronal circuits with vital importance for the development of cognitive
functions and memory and learning formation. Glud2 is a new gene that is found in primates
and it was evolved under positive Darwinian selection. The isoform of glutamate
dehydrogenase, hGLUD2, that is coded by this gene, is implicated in glutaminergic
transmission and it possesses important abilities of resistance and differential regulation of
the enzyme during high requirements of the glutamatergic system due to evolutionary
changes to its structure (Gly456Ala and Arg443Ser). The focus of the present study is the
delineation of the behavioral phenotype of GLUD2 transgenic mice (Tg), that a part of
human chromosome X is inserted in their genome containing GLUD2 and its promoter,
regarding mobility and mobility-related learning and memory. Studies in brains of Tg mice
had shown that the human gene is expressed in the mouse brain in a similar pattern to human
brains, ensuring reliability of the studies. The role of this gene remains to be elucidated,
however several studies show activation of hGDH2 during prenatal and early postnatal
developmental periods of the brain, contributing to developmental changes in the prefrontal
cortex and dysregulation of this activation is related to epileptic syndromes,
neurodegenerative diseases and neoplasias. Therefore, the study of the behavioral phenotype
of transgenic GLUD2 mice could provide more information about the base of intelligence,
the biological substrate of diseases and be an important therapeutic target of homeostatic
brain regulation.
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| Language |
English |
| Subject |
Behavioral phenotype of GLUD2 |
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Expression of brain hGDH2 |
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Έκφραση ισομορφής hGDH2 εγκεφάλου |
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Διαγονιδιακά ποντίκια |
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Φαινότυπος συμπεριφοράς GLUD2 |
| Issue date |
2022-03-30 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/d/b/a/metadata-dlib-1650006252-711599-747.tkl
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| Views |
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