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Identifier 000383673
Title Πρωτεϊνες που ρυθμίζουν τα επίπεδα και τις λειτουργίες της HDL : νέες προοπτικές για τη θεραπεία της καρδιαγγειακής νόσου
Alternative Title Proteins that regulate the levels and functions of HDL:
Author Φωτάκης, Παναγιώτης
Thesis advisor Καρδάσης, Δημήτριος
Select a value Πανεπιστήμιο Κρήτης.
Abstract 1 ABSTRACT Many studies have shown that HDL has a plethora of functions that may contribute to the protection from cardiovascular disease. The pathway of the biogenesis and catabolism of HDL is a complex process and involves several membrane bound and plasma proteins. Using adenoviruses mediated gene transfer in various mouse models, the studies described in this thesis explore the pathway of the biogenesis of HDL and more specifically the following: 1. The importance of the hydrophobic residues in the 218-230 region of apoA-I in the biogenesis of HDL. 2. The effects of LCAT mutations on the biogenesis of HDL. 3. The effects of CTα on the biogenesis of HDL. 4. The contribution of dominant mutations in apoE to lipid homeostasis and the biogenesis of HDL. 5. The synergy of apoA-IV and LCAT on the biogenesis of apoA-IV containing HDL. 6. The effect of reconsituted HDL containing apoE and apoA-I on endothelial gene expression.
Language English
Subject Atherosclerosis
Cardiovascular disease
Cholesterol
HDL
Αθηροσκλήρωση
Καρδιαγγειακή νόσος
Χοληστερόλη
Issue date 2014-07-24
Collection   Faculty/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/0/1/e/metadata-dlib-1397548249-24440-6977.tkl Bookmark and Share
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