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Identifier 000430965
Title Αξιολόγηση ογκομετρικών μεθόδων για τον οφθαλμικό κόγχο
Alternative Title Clinical applications of volumetric analysis in the human orbit
Author Μπόντζος, Γεώργιος
Thesis advisor Δετοράκης, Ευστάθιος
Reviewer Μαρής, Θωμάς
Μαζωνάκης, Μιχαήλ
Τσιλιμπάρης, Μιλτιάδης
Χλουβεράκης, Γρηγόρης
Ξεκούκη, Παρασκευή
Εφροσύνη, Παπαδάκη
Abstract Purpose: Orbital volume measurements comprise an essential clinical tool for managing several morbidities of the orbital area. In the presented work, we investigate methods that can provide precise measurements of the orbital volume and its contents (eye globe, extraocular muscles, optic nerve). Furthermore, clinical evaluation of these calculations is provided by examination of patients affected with orbital disease. Methods: We tested manual, semi-automated and fully automated methods for their validity and repeatability in orbital, eyeball, muscle and nerve volumetry. Methods were applied in computed tomography and magnetic resonance imaging series. Estimations were expanded in patients with high myopia and hyperopia where there is significant imbalance between eyeball position and orbital volume. Moreover, patients affected by thyroid eye disease underwent volume measurements with a view to evaluate extraocular muscle volume and disease status. Results: Methods of manual planimetry and semi-automated stereology were selected for further analysis regarding their validity. An algorithmic approach of volume measurements for the orbit and its contents was set. In the clinical part of this work, the effective orbital volume was measured in patients with high myopia and clinical correlations between volumes and anthropometric variables were examined. In patients affected by thyroid eye disease, 3D muscle volumetry was performed and results were compared to standard 2D evaluation of muscle diameter for estimating disease status. Conclusions: The human orbit is prone to several pathologies including inflammatory disease, tumors, congenital malformations and fractures of its walls. Alterations in orbital volume can affect the harmonious anatomy between the fine structures of the orbit and may manifest with symptoms such as exophthalmos, enophthalmos and diplopia. Precise measurement of the orbital volume is of utmost importance for performing orbital surgery, as vulnerable vessels and nerves can be damaged during surgical approach. In daily practice, orbital volume measurement is often underestimated due to the laborious and time consuming methods. Objective approaches are often used instead which may lead to inaccurate results. By applying the systemic approach along with the presented algorithms we can achieve meaningful results and minimize the required time for calculations.
Language Greek
Subject Eye
Volume measurement
Μέτρηση όγκου
Issue date 2020-08-05
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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