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Identifier uch.med.phd//1998DIS0156
Title Ανίχνευση Κ-RAS μεταλλάξεων και αστάθεια του μικροδορυφορικού DNA στο βρογχογενή καρκίνο
Alternative Title K-RAS Mutations and microsatelline instability in bronchogenic carcinoma
Creator Froudarakis, Marios Em
Abstract Microsatellite instability (MI), loss of heterozygocity(LOH) and K-ras mutatios are defected in lung cancer specimens. However, their importance tumorigenesis remains unknown. The aim of this study was to idehtify the presence of MI, LOH and K-ras mutations in non-small-cell lung carcinoma (NSCLC). Methods: We performed biopsies from the tumor and form the opposite site normal bronchial mucosa in 20 patients with NSCLC. All paired speciments were studied using PCR technique for MI and LOH on chromosomes 17p, 17q, 9p, 9q, with ten polymorphic markets. Tumor DNA was also studied for K-ras mutations. Results: From 20 paired speciments, genetic alterations were found in 16 tumors (80%). Eleven tumors (55%) exhibited MI while 10 tumors(50%) exhibited LOH. The most frequent incidence of LOH was found for the 17q21, whereas of MI was 17p. K-ras mutatons in codon 12 were 8/20 (40%), 6 of them displayed MI concurrently (odd ratio=4.2). Conclusion: MI, LOH and K-ras mutations are depicted in DNA from biopsies of NSCLC. MI appears to be a novel molecular in NSCLC and may affect mutations in K-ras oncogene.
Issue date 1998-02-01
Date available 1998-04-5
Collection   Faculty/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/1/8/a/metadata-dlib-1998DIS0156.tkl Bookmark and Share
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