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Identifier

000454734

Title

Ο ρόλος της κυτταρομείωσης και της ενδοπεριτοναϊκής χημειοθεραπείας στην αντιμετώπιση των γυναικολογικών κακοηθειών

Alternative Title

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of gynecological malignancies

Author

Φραγκίσκος, Ιωάννης

Thesis advisor

Λασιθιωτάκης, Κωνσταντίνος

Reviewer

Ζώρας, Οδυσσέας
Βρεκούσης, Θωμάς

Abstract

The role of cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of gynecological malignancies has been evaluated in several clinical studies and meta-analyses, but it is still the subject of scientific controversy. Therefore, a systematic review of existing meta-analyses was performed to summarize the results of the use of HIPEC and CRS in the management of gynecological cancers. The search included MEDLINE, Cohrane Library, Scopus, Prospero, Web of Science and Science and Science Direct, Google Scholar databases for meta-analyses of randomized controlled trials and observational studies for 4 different types of gynecological cancers. Endometrial cancer, cervical cancer, Uterine leiomyosarcoma and ovarian cancer. Results vary depending on the type of cancer. The present overall study suggests that HIPEC performed at the end of CRS appears to benefit patients treated for primary ovarian disease, while the evidence is insufficient to establish a clinical benefit of CRS combined with HIPEC for endometrial cancer, cervical cancer and uterine leiomyosarcoma.

Language

Greek, English

Subject

Gynecological cancer

HIPEC

Meta-analysis

Peritoneal carcinomatosis(PC)

Γυναικολογικός καρκίνος

Περιτοναϊκή καρκινωμάτωση (PC)

Issue date

2023-04-05

Collection