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Identifier	000399409
Title	Η έκφραση των πρωτεϊνών YKL-40 και MIP-1a στις υπεζωκοτικές συλλογές
Alternative Title	Expression of YKL-40 and MIP-1a in exudates and transudαtes
Author	Αδαμίδη, Τώνια
Thesis advisor	Σιαφάκας, Νικόλαος Σουρβίνος, Γιώργος Σχίζα, Σοφία
Reviewer	Τζανάκης, Νικόλαος Αντωνίου Αικατερίνη Τσατσάνης, Χρήστος Σαμώνης, Γεώργιος
Abstract	Background: YKL-40 is an extracellular matrix glycoprotein with a significant role in tissue inflammation and remodeling. MIP-1a has chemotactic and pro-inflammatory properties, and is induced by YKL-40 in several lung disorders. The aim of this study was to determine the levels of YKL-40 and MIP-1a in blood serum and pleural fluids of various pulmonary diseases, and to evaluate their potential role as differential diagnosis biomarkers. Methods: We recruited 60 patients (age: 62.5±20.6 years) with pleural effusions: 49 exudates and 11 transudates (T). Exudates were further classified based on the underlying disease: 10 with tuberculosis (TB), 13 with lung cancer (LCa), 15 with metastatic cancer (MCa) of non-lung origin and 11 with parapneumonic (PN) effusions. YKL-40 and MIP-1a levels were measured by ELISA. Results: Pleural YKL-40 levels (ng/ml) were similar among all patient groups (TB: 399±36, LCa: 401±112, MCa: 416±34, PN: 401±50, T: 399±42, p=0.92). On the contrary, YKL-40 was significantly lower in the serum of TB patients (TB: 58±22, LCa:212±106, MCa: 254±140, PN: 265±140, T: 229±123, p<0.001). Pleural MIP-1a protein levels (ng/ml) were statistically lower only in patients with LCa (TB: 25.0±20.2, LCa:7.3±6.0, MCa: 16.1±14.9, PN: 25.4±27.9, T: 18.5±7.9, p=0.012), a finding also observed in serum MIP-1a levels (TB: 17.1±7.6, LCa: 9.4±7.0, MCa: 28.7±28.7, PN:33.3±24.0, T: 22.9±8.7, p=0.003). Conclusions: Our data suggest that both YKL-40 and MIP-1a, particularly in serum, could prove useful for the differentiation of pleural effusions in clinical practice, especially of TB or LCa origin. However, large-scale studies are needed to validate these findings.
Language	Greek
Subject	Biomarkers
	Metastatic cancer
	Tuberculosis
	Βιοδείκτες
	Καρκίνος του πνεύμονα
	Μεταστατικός καρκίνος
	Φυματίωση
Issue date	2016-03-24
Collection	School/Department--School of Medicine--Department of Medicine--Doctoral theses
	Type of Work--Doctoral theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/5/1/b/metadata-dlib-1455608885-57264-29022.tkl
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