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| Identifier |
000403394 |
| Title |
Study of the role of dendrites in the orientation tuning of a single L2/3 pyramidal neuron model |
| Alternative Title |
Μελέτη του ρόλου των δενδριτών στην προτίμηση προσανατολισμού σε ένα μοντέλο πυραμιδικού νευρώνα των στιβάδων 2/3 του πρωτοταγούς οπτικού φλοιού |
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Author
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Κοντοδήμου, Γεωργία
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Thesis advisor
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Παϊράζη, Παναγιώτα
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Reviewer
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Σιδηροπούλου, Κυριακή
Θερμού, Κυριακή
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| Abstract |
Orientation tuning, i.e. the preferential response to stimuli with a par¬ticular orien- tation, is a fundamental feature selection process occurring in V1. Although it has been more than half a century that Hubel and Wiesel conducted their pioneering studies on the visual system, the dendritic basis of orientation preference has just started to be deciphered. In addition, the morphology of the pyramidal neuron with its apical and basal trees lying in different layers of the cortex and thus receiving inputs of distinct nature, could endow with specific and distinct roles in sensory processing.
In this study we investigate the role of basal and apical trees, as well as the role of dendritic spikes in orientation tuning at the single cell level by implementing a biophysically and morphologically detailed reconstruction of a layer 2/3 V1 mouse neuron using the NEURON simulation environment. To assess the possible contribution of biophysical mechanisms we simulate the blockade of voltage-gated Na + channels and/or NMDARs in basal andapical dendrites and we perform both somatic and dendritic recordings.
Our results show that orientation tuning of the neuron seems to follow the tuning of the basal tree. In addition, blockade of both the NMDARs and the voltage-gated Na + channels, under increase in AMPA conductance, showed that the basal tree has a more significant role in shaping orientation selectivity in layer 2/3 V1 pyramidal neurons. Regarding dendritic spikes, we observed Na + spikes and we found that they are significantly less in the orthogonal orientation. We failed to observe NMD A spikes, but this needs to be further analyzed.
In conclusion, our study helps to dissect the contributions of two key ionic conduc- tances found in the dendrites of layer 2/3 V1 mouse neurons. Moreover, we suggest a dominant role of the basal rather than the apical tree in fine tuning the orientation preference of these cells.
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| Language |
English |
| Issue date |
2016-12-13 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/c/7/1/metadata-dlib-1482496452-808299-10802.tkl
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| Views |
165 |
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