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Identifier 000402074
Title Εφαρμογή της Βιοκατάλυσης προς την χημειοενζυμική σύνθεση των φερομονών του κανθάρου των φοινικοειδών Rhynchophorus spp.
Alternative Title Application of Biocatalysis for chemoenzymatic synthesis of natural pheromones from red palm weevil Rhynchophorus spp.
Author Διονυσοπούλου Χρυσούλα Δ.
Thesis advisor Σμόνου, Ιουλία
Reviewer Βασιλικογιαννάκης, Γεώργιος
Στρατάκης, Μανώλης
Abstract In the present thesis the first chemoenzymatic synthesis of the natural pheromones of red palm weevil Rhynchophorus spp has been accomplished. The key step of these syntheses is the reduction of keto-esters to hydroxyl-esters with the desirable stereoselectivity. Firstly, racemic products from chemical reduction were synthesized in order to use them as standards and help us to indentify the products of the enzymatic reductions. The next study was to determine which commercial ketoreductase is proper for each synthesis. In order to succeed this we use a variety of commercially available ketoreductases. For the control of enzymatic reductions we used GC with chiral column and the suitable program for our substrates. All ketoreductases that were used for our synthesis, are NADPH-dependent ketoreductases. The absolute configuration of all products derived from enzymatic reductions was determined by NMR spectroscopy.
Language Greek
Subject NADPH εξαρτώμενες κετορεδουκτάσες
NAPDH - dependent ketoreductase
Φερομόνες συνάθροισης του κανθάρου των φοινικοειδών
Issue date 2016-07-22
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
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