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Identifier	000404276
Title	Ο ρόλος των CB2 υποδοχέων των κανναβινοειδών σε διεργασίες ανταμοιβής
Alternative Title	Contribution of CB2 cannabinoid receptors in reward processes
Author	Νικολάου Κατερίνα
Thesis advisor	Παναγής, Γεώργιος
Reviewer	Καστελλάκης, Ανδρέας Θερμού, Κυριακή
Abstract	Early studies in the existing literature suggest that CB2 cannabinoid receptors (CB2Rs) play a major role in modulating motivation and reward processes. This Master’s research is focused on understanding CB2Rs’ implication in brain-reward systems responsible for the expression of reinforcing properties of drugs of abuse, such as cocaine, and providing further evidence that the endocannabinoid system could be explored as a potential drug discovery target for the treatment of drug addiction and reward-dysfunction-related disorders. The aim of this study was to examine the effects of JWH133, a potent CB2R agonist, on the systemic cocaine-induced potentiation of brain-stimulation reward using the intracranial self-stimulation (ICSS) paradigm. Therefore, we ivestigated the effects of local administration of JWH-133 into the ventral tegmental area (VTA) on the rewarding efficacy of cocaine. In order to verify the specificity of CB2R’s implication, reversal of JWH-133 effects was investigated by pre-tratment with the CB2R antagonist SR144528. Thus, the effects of the different drugs used on the rewarding efficacy of self-stimulation were inferred using the curve-shift intracranial self-stimulation paradigm. Our study indicates that intra-VTA administration of JWH-133 was able to affect the reward-facilitating effect of cocaine and that these effects were blocked by pre-administration of SR144528, suggesting CB2R-mediated effects. These findings support a common conclusion that CB2Rs may constitute new targets in medication development for treatment of substance abuse and addiction.
Language	Greek, English
Subject	Addiction
	Εθισμός
Issue date	2016-12-13
Collection	School/Department--School of Medicine--Department of Medicine--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/5/c/d/metadata-dlib-1483961541-7537-8768.tkl
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