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Identifier 000397429
Title Μελέτη τοξικολογικών και βιοδραστικών ιδιοτήτων υδατικών εκχυλισμάτων του φυτού Opuntia ficus-indica (φραγκόσυκο) σε in vitro συνθήκες
Alternative Title In vitro toxicological assessment of extracts derived by cactus Opuntia ficus-indica
Author Ραπτάκη, Ηλιάνα Π.
Thesis advisor Κουτσολέλος, Αθανάσιος
Reviewer Κυριακοπούλου, Κατερίνα
Τσατσάκης, Αριστείδης
Abstract Opuntia focus Indica is an important food source with a global distribution and a high nutritional and commercial value. Besides being consumed as food, most portions of the cactus plant have been used in folk medicine, e.g as emollient, moisturizing, cicatrizing, hypocholesterolemic and hypoglycemic agents. In modern times, many studies confirmed the biological efficiency of the plant against several diseases as well. In view of the interest paid overtime on O.ficus indicia, we performed a comparative study on the chemical content and the biological activity and toxicity of the different parts of this cactus species ( Cladode, fruit Flesh, fruit peel, flower and seed). Plant Material was received from local producers of the southern Peloponnese ( Greece). Extraction were carried out in H2O using a Branson Ultrasonic bath. The MTT ( 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to determine viability/cytotocity of HepG2 and Hela cells and the Comet assay to determine DNA damage and to investigate potential protective effects of the extracts against H2O2 – induced DNA damage. Opuntia ficus Indicia ( OF) extracts were neither cytotoxic to HepG2 and Hela cells nor genotoxic to HepG2 cells at all concentration tested. Moreover, a 24h incubation with OF extracts significantly reduced H2O2 –induced DNA damage in HepG2 cells. As conclusion, the absence of any cytotoxic effect of the extracts in combination to the protective, antioxidant and effect many of them, emphasize the potential role of this plant in the overall well being.
Language Greek
Subject Toxicology
Τοξικολογία
Issue date 2015-11-20
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/b/6/2/metadata-dlib-1448620120-280220-17626.tkl Bookmark and Share
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