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Identifier 000402067
Title Investigation of the role of TPL2 in colon cancer
Alternative Title Μελέτη της επίδρασης της TPL2 στον καρκίνο του παχέος εντέρου
Author Σαλιακούρα, Μαρία
Thesis advisor Ηλιόπουλος, Αριστείδης
Reviewer Δράκος, Ηλίας
Τσατσάνης, Χρήστος
Abstract Colorectal cancer is the third most common cancer worldwide and the second most common in developed countries. Its pathogenesis is attributed to both genetic and epigenetic events that take place with tumor initiation and progression. Patient prognosis and individual response to therapy varies significantly in stage-independent manner, mainly due to molecular heterogeneity. In this regard, there is an ongoing attempt to identify specific biomarkers that will allow predicting a patient’s clinical outcome beyond tumor staging, and facilitate a more effective therapeutic approach. TPL2 kinase has a contradictory role in cancer, exhibiting tumor-promoting or tumor-suppressing properties in a tissue-specific manner. In the present study, we aimed to delineate the role of TPL2 in colon cancer, a field that remains, to date, poorly elucidated. Using established human colon cancer cell lines, we proceeded to TPL2 inhibition and tpl2 gene silencing. We show that inhibition of TPL2 significantly affects the proliferative and clonogenic capacity of cell lines HT29 and HCT15. Conversely, silencing tpl2 does not lead to similar results. Overall, our findings suggest that although TPL2 may have a role in colon cancer cell proliferation, TPL2-independent pathways also seem to be crucially involved.
Language English
Subject Κινάση
Issue date 2016-07-19
Collection   Faculty/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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