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Identifier 000417008
Title H τροποποίηση της μικροβιακής χλωρίδας στην πρόληψη των ιδιοπαθών φλεγμονωδών νόσων του εντέρου
Alternative Title Modulation of gut microbiota as prevention for Inflammatory Bowel Disease
Author Λούκα, Μαγδαληνή
Thesis advisor Γαλανάκης, Εμμανουήλ
Select a value Πανεπιστήμιο Κρήτης.
Abstract Over the past two decades, there has been significant progress in understanding the pathogenesis of IBD. Nowadays, it is thought that IBD are complex, multifactorial disorders, in which genetic factors, environment and microbiota lead to an aberrant response of the immune system. Advances in genomic sequencing technology has facilitated the evaluation of gut microbiota in health and disease. Multiple studies have documented differences in the composition of the gut microbiota between patients with IBD and healthy individuals, particularly with respect to microbial diversity and the relative abundance of specific bacterial taxa. This condition has been defined as "dysbiosis" and is a constant finding in IBD patients, suggesting that scientists could modify the microbiota in order to prevent the disease itself and its relapses. Strategic interventions to be studied in this review include diet, probiotics, prebiotics and symbiotics, as well as antibiotics and faecal transplantation. Indeed, diet is one of the main regulators of microbiota. Today, due to the increased prevalence of the disease in the Western world, many researchers support the possible correlation of diet in disease development. They also examine whether the partial enteral nutrition, following the spectacular effects of exclusive enteral nutrition in the induction of remission, is effective in maintaining remission in patients with Crohn's disease. Besides, probiotics, prebiotics and synbiotics are reasonably considered as a possible intervention because of their ability to promote the growth of beneficial bacteria in the intestinal microflora. However, so far, their results are limited to patients with ulcerative colitis and pouchitis. In addition, antibiotics can cause dysbiosis or eubiosis of the intestinal microflora. Over the last decade, many studies have linked increased antibiotic use to the development of IBD and, at the same time, some antibiotics are being studied to maintain remission, although they pose safety issues. Finally, faecal transplantation is a promising method that has been used for 60 years in the treatment of pseudomembranous colitis and is now being studied in IBD. Modification of microflora is a promising option for maintaining and restoring intestinal homeostasis. So far, its results are variable, but at the same time they raise many concerns that form the basis for understanding its role in the prevention of IBD. .
Language Greek
Subject Antibiotics
Fecal microbiota tranplantation
Μεταμόσχευση κοπράνων
Issue date 2018-07-18
Collection   Faculty/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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