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Identifier 000376024
Title Ανάπτυξη αντιγονοειδικής ανοσολογικής απόκρισης σε εμφυτεύσιμα νανοδομημένα υποστρώματα πυριτίου
Alternative Title Development of antigen-specific immune response on transplantable microstructured silicon substrates
Author Ζέρβα, Ιωάννα Διομήδης
Thesis advisor Αθανασάκη, Ειρήνη
Reviewer Φωτάκης, Κώστας
Γκιζέλη, Ηλέκτρα
Abstract The surface and interface properties of biomaterials are determined from the synergy of the surface morphology and chemistry. Specific combinations of chemical and topographical cues, similar to those experienced by cells during in vivo development, have been shown to provide control over cellular adhesion and migration. The aim of the present study is to employ ultrafast laser texturing technologies to develop artificial transplantable biomaterials scaffolds able to preferentially control the adhesion properties of cells stimulating the immune response as a safer alternative to vaccines. Vaccination protocols so far, force stimulation towards a specific antigen by inducing adjuvant-mediated non-specific inflammation, which however, is responsible for several side effects. The success of vaccines is also limited by the selection of specific non-infectious antigenic epitopes, which because of the extended polymorphism of histocompatibility antigens will not have high affinity for all individuals. The present study aims to produce personalized transplantable vaccines. Pre-activated macrophages absorbed on transplantable surfaces are able to stimulate the development of immune response. Such approach eliminates side effects due to the adjuvants, while leaving the natural selection mechanism of antigen loading to choose the right antigenic epitope for each individual. The surfaces to be used herein consist of properly functionalized 3D micro and submicron textured scaffolds fabricated by ultrafast laser The 3D scaffolds displaying the capacity to exquisitely control the size of pores, the micro/nanotopography, the surface chemistry and distribution of bioactive species, represent significant progress beyond the current state of the art enabling a multi-parametric assessment of various factors affecting cell behavior, with far-reaching implications human health. This interdisciplinary proposal is expected to produce basic knowledge for further exploitation.
Language Greek
Subject Immune response
Ανοσολογική απόκριση
Issue date 2012-11-16
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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