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Identifier	000409405
Title	Μελέτη του οξειδωτικού στρές σε ανοιχτή και λαπαροσκοπική κολεκτομή για καρκίνο παχέος εντέρου και ορθού
Alternative Title	Oxidative stress study in open and laparoscopic colectomy in patients with colorectal cancer
Author	Παππάς-Γώγος, Γεώργιος
Thesis advisor	Χρυσός,Εμμανουήλ
Select a value	Καστανάς, Ηλίας Ζώρας, Οσυσσέας
Abstract	Background: Colorectal cancer as well as colorectal surgery is associated with increased oxidative stress through different mechanisms. In this study the levels of different oxidative stress markers were comparatively assessed in patients who underwent laparoscopic or conventional resection for colorectal cancer. Methods: Sixty patients with colorectal cancer were randomly assigned to undergo laparoscopic (LS) or open surgery (OS). Lipid, protein, RNA, and nitrogen damage was investigated by measuring serum 8-isoprostanes (8-epiPGF2a), protein carbonyls (PC), 8-hydroxyguanosine (8-OHG), and 3-nitrotyrosine (3-NT), respectively. The primary end point of the study was to analyze and compare serum levels of the oxidative stress markers between the groups. Results: Postoperative serum levels of 8-epiPGF2a, 3-NT, and 8-OHG were significantly lower in the LS group at 24 h after surgery (p < 0.05). At 6 h postoperatively, the levels of 8-epiPGF2a and 3-NT were significantly lower in the LS group (p < 0.05). No difference in the levels of PC was found between the two groups at any time point. In the OS group, postoperative levels of 8-epiPGF2a were significantly lower than the preoperative values (p < 0.01). In the LS group, the postoperative values of 8-epiPGF2a, 3-NT, and 8-OHG were significantly lower than the pre- operative values (p < 0.05). Conclusion: Laparoscopic surgery for colorectal cancer is associated with lower oxidative stress compared to open surgery. 8-epiPGF2a was the most suitable marker for readily defining the oxidative status in patients who underwent surgery for colorectal cancer.
Language	Greek
Subject	Ορθοκολικός καρκίνος
Issue date	2017-07-26
Collection	School/Department--School of Medicine--Department of Medicine--Doctoral theses
	Type of Work--Doctoral theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/4/1/6/metadata-dlib-1505389054-526054-19141.tkl
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