Your browser does not support JavaScript!

Home    Search  

Results - Details

Search command : Author="Σμόνου"  And Author="Ιουλία"

Current Record: 30 of 45

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Identifier 000395116
Title Χημειοενζυμική σύνθεση οπτικώς καθαρών φυσικών προϊόντων και χειρομορφών ενδιάμεσων
Alternative Title Chemoenzymatic synthesis of optically pure natural products and chiral intermediates
Author Μπαριωτάκη, Άννα
Thesis advisor Σμόνου, Ιουλία
Reviewer Στρατάκης, Μανώλης
Ξενάκης, Αριστοτέλης
Κατερινόπουλος, Χαράλαμπος Ε.
Βασιλικογιαννάκης, Γεώργιος Ε.
Μπουριώτης, Βασίλης
Βελώνια, Κέλλυ
Abstract In the present thesis the stereoselective enzymatic reductions with NADPHdependent ketoreductases for the synthesis of important chiral intermediates were studied and more specifically for the synthesis of optically pure hydroxy-keto esters,1,3-dihydroxy esters and α- or γ-substituted hydroxy-keto esters. Also, a chemoenzymatic approach for the synthesis of the natural product (R)- Goniothalamin has been accomplished. All products derived from enzymatic reductions were analyzed and characterized and their absolute configuration was determined by NMR spectroscopy. These research projects were accomplished under the Research Program HRAKLEITOS II. In the first part, the enzymatic reduction of tert-butyl 3,5-dioxo-hexanoate for the synthesis of 3,5-dihydroxy esterswas completed, in a two-step, one-pot method in the same reaction vessel, without the isolation of the intermediate. These products were synthesized with excellent optical purity and chemical yield. Ketoreductases proved to be excellent catalysts with high stereoselectivity and chemoselectivity. The next part included the studies for the enzymatic reduction of tert-butyl- 2-methyl-3,5-dioxo-hexanoate for the synthesis of 2-methyl-5-hydroxy-3-keto esters. The products were formed in excellent optical and chemical purity with high enantiomeric and diastereomeric excess. Also, the enzymatic reduction of tert-butyl-4-methyl-3,5-dixo-haxanoate was studied for the synthesis of 4-methyl-5-hydroxy-3-keto esters and 4-methyl-3- hydroxy-5-keto esters with high stereoselectivity and high enantiomeric and diastereomeric excesses. In the next part the chemoenzymatic approach for the synthesis of the natural product (R)-Goniothalamin, an anti-proliferative agent is presented. In the last part the investigation of a new photocatalyst of graphitic Carbon Nitride, for the oxidation of cyclohexanol to cyclohexanone, is described.
Language Greek
Subject Biocatalysis
Enzymatic oxidation
Enzymatic reduction
Graphitic Carbon Nitride
Ketoreductases
NADPH
Oxidoreductases
Βιοκατάλυση
Ενζυμική αναγωγή
Ενζυμική οξείδωση
Κετορεδουκτάσες
Κυκλοεξανόνη
Οξειδορεδουκτάσες
Issue date 2015-07-13
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Chemistry--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/e/d/b/metadata-dlib-1436346647-312304-4578.tkl Bookmark and Share
Views 332

Digital Documents
No preview available

View document
Views : 7